摘要
目的探讨炙甘草汤合猪苓汤加减联合呋塞米治疗肝硬化腹腔积液临床效果。方法选取2020年1月至2021年5月在南京中医药大学附属苏州市中医医院治疗的84例肝硬化腹腔积液患者,根据随机数字表法分为两组,对照组使用常规西医治疗,在此基础上,观察组使用炙甘草汤合猪苓汤加减治疗,对比两组的临床疗效、症状消失时间、体征变化、肝功能及肝纤维化指标。结果观察组治疗总有效率为92.86%,高于对照组的71.43%,差异有统计学意义(P<0.05);观察组腹腔积液、腹胀、腹痛、下肢水肿消失时间明显短于对照组,差异有统计学意义(P<0.05);观察组治疗后腹围、脾脏厚度、体重均小于对照组,差异有统计学意义(P<0.05);观察组治疗后谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBIL)、Ⅲ型前胶原(PC-Ⅲ)、血清透明质酸(HA)、层粘连蛋白(LN)低于对照组,白蛋白(Alb)高于对照组,差异均有统计学意义(P<0.05)。结论炙甘草汤合猪苓汤加减联合呋塞米治疗肝硬化腹腔积液临床疗效显著,能加快症状缓解速度,明显改善体征,抑制肝纤维化,保护肝功能。
Objective To investigate the clinical effect of Zhigancao Decoction and Zhuling Decoction with modified dosage combined with furosemide in the treatment of hepatocirrhosis ascites.Methods A total of 84 patients with hepatocirrhosis ascites treated in Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from January 2020 to May 2021 were divided into two groups according to the random number table.The control group was treated with conventional Western medicine,while the observation group was treated with Zhigancao Decoction and Zhuling Decoction on the basis of the former treatment.The clinical efficacy,time to symptom disappearance,sign changes,liver function and liver fibrosis indexes were compared between the two groups.Results The total effective rate of treatment in the observation group was 92.86%,which was higher than 71.43%in the control group,with statistically significant differences(P<0.05);The time to disappearance of various symptoms such as ascites,abdominal distension,abdominal pain,and lower limb edema in the observation group was significantly shorter than that in the control group,with statistically significant differences(P<0.05);After treatment,the abdominal circumference,spleen thickness,and body mass of the observation group were smaller than those of the control group,with statistically significant differences(P<0.05);After treatment,the aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL),typeⅢprocollagen(PC-Ⅲ),serum hyaluronic acid(HA),laminin(LN)in the observation group were lower than those of the control group,but the albumin(Alb)was significantly higher than the control group,all with statistically significant differences(P<0.05).Conclusion The treatment of Zhigancao Decoction and Zhuling Decoction combined with furosemide has a significant clinical effect on hepatocirrhosis ascites.It is able to speed up the remission of symptoms,significantly improve the signs,inhibit liver fibrosis,and protect liver function.
作者
吴必建
杰辉
章一凡
WU Bijian;JIE Hui;ZHANG Yifan(Department of Spleen and Stomach Diseases,Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Jiangsu,Suzhou 215000,China)
出处
《中国医药科学》
2022年第4期25-28,共4页
China Medicine And Pharmacy
关键词
肝硬化腹腔积液
炙甘草汤合猪苓汤加减
呋塞米
肝功能
肝纤维化
Hepatocirrhosis ascites
Zhigancao Decoction and Zhuling Decoction
Furosemide
liver function
Liver fibrosis
