摘要
路氏小体病变在可观测的脑区部位积累是帕金森病的主要临床特征。对于缺乏路氏小体病理证据的血管型帕金森病来说,其临床特征主要是与年龄相关的脑白质病变症状共同存在。脑白质病变常在老年人群、阿尔茨海默病患者和血管性痴呆患者中存在,主要导致患者的认知功能损害,但对于帕金森病和脑白质病变两种症状共存的研究因评估脑白质损伤负荷的方法和选择的患者群体不同而有所差异。该文对关于脑白质病变与血管型帕金森共病现象和影响的文献进行综述,并提出脑白质损伤可能加重或促进与帕金森病相关的一些运动和认知障碍的观点,为日后相关研究指明方向。
The accumulation of pathologic lesions in observable brain regions is the main clinical feature of Parkinson's disease.For vascular Parkinson's disease that lacks pathological evidence of Lushi body,its clinical features are mainly coexisting with age-related white matter lesions.White matter lesions often exist in elderly people,patients with Alzheimer's disease and patients with vascular dementia,and they mainly cause cognitive impairment in patients.However,the study of the coexistence of the two symptoms of Parkinson's disease and white matter lesions differs depending on the method of assessing the burden of white matter damage and the selected patient groups.This article reviews the literature on the comorbidity and influence of white matter lesions and vascular Parkinson's disease.The article also puts forward the view that brain white matter damage may aggravate or promote some motor and cognitive impairments related to Parkinson's disease,which points out the direction for future relevant research.
作者
黄广苏
陆菲
覃彬
HUANG Guangsu;LU Fei;QIN Bin(Department of Neurology,Liuzhou People's Hospital,Liuzhou,Guangxi Zhuang Autonomous Region,545006 China)
出处
《系统医学》
2022年第1期189-193,共5页
Systems Medicine
基金
2021年度广西壮族自治区卫健委西医类别自筹经费科研项目(20210277)。
关键词
帕金森病
脑白质病变
认知障碍
Parkinson's disease
White matter lesions
Cognitive impairment
