摘要
目的:观察血清免疫球蛋白(Ig)M、IgA、IgG与系统性红斑狼疮(SLE)患者疾病活动度(SLEDAI)的相关性。方法:选取104例SLE患者为研究对象,设为SLE组。根据SLEDAI评分将SLE组再分为轻度组(n=37)、中度组(n=35)、重度组(n=32)。另选取同期42名于本院进行体检的健康者作为对照组。各组均进行血清IgM、IgA、IgG水平测定,比较SLE组和对照组IgM、IgA、IgG水平;比较轻度组、中度组、重度组IgM、IgA、IgG水平;进行Pearson相关性分析,分析血清IgM、IgA、IgG水平与SLEDAI评分的相关性。结果:SLE组IgM、IgA、IgG水平均明显高于对照组,差异有统计学意义(P<0.05);重度组IgM水平明显低于中度组和轻度组,且中度组明显低于轻度组;重度组IgA、IgG水平均明显高于中度组和轻度组,且中度组明显高于轻度组,差异有统计学意义(P<0.05);Pearson相关性分析结果显示,SLE患者血清IgM水平与SLEDAI评分呈负相关(r=-0.352,P<0.05),血清IgA、IgG水平与SLEDAI评分呈正相关(r=0.422、0.478,P<0.05)。结论:SLE患者血清IgM水平与SLEDAI评分呈负相关,血清IgA、IgG水平与SLEDAI评分呈正相关。
Objective:To observe correlations among serum immunoglobulin(Ig)M,IgA,IgG levels and disease activity(SLEDAI)in patients with systemic lupus erythematosus(SLE).Methods:104 SLE patients were selected as the research subjects and set as SLE group.According to the SLEDAI score,the SLE group was further divided into mild group(n=37),moderate group(n=35),and severe group(n=32).Another 42 healthy people who underwent physical examination in our hospital during the same period were selected as control group.The serum IgM,IgA and IgG levels were measured in each group.The levels of IgM,IgA and IgG in the SLE group and the control group were compared,and the levels of IgM,Ig A and IgG in the mild,moderate and severe groups were also compared.Pearson correlation analysis was performed to analyze the correlations among the serum IgM,IgA,IgG levels and SLEDAI score.Results:The levels of IgM,IgA and IgG in the SLE group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The level of IgM in the severe group was significantly lower than those in the moderate and mild groups,and that in the moderate group was significantly lower than that in the mild group;the levels of IgA and IgG in the severe group were significantly higher than those in the moderate and mild groups,and those in the moderate group were significantly higher than those in the mild group;and the differences were statistically significant(P<0.05).The Pearson correlation analysis showed that the serum IgM levels in the SLE patients were negatively correlated with the SLEDAI scores(r=-0.352,P<0.05);while the serum IgA and IgG levels were positively correlated with the SLEDAI scores(r=0.422,0.478,P<0.05).Conclusions:The serum IgM levels in the SLE patients are negatively correlated with the SLEDAI scores,while the serum IgA and IgG levels are positively correlated with the SLEDAI scores.
作者
胡世坤
HU Shikun(Laboratory Department of Pingdingshan the Second People’s Hospital,Pingdingshan 467000 Henan,China)
出处
《中国民康医学》
2022年第3期112-114,共3页
Medical Journal of Chinese People’s Health
