摘要
目的:探讨炎症性肠病患者的血清白细胞介素-6(IL-6)、可溶性细胞黏附分子-1(sICAM-1)、脂肪细胞因子(chemerin)的水平变化与意义。方法:选择2017年2月-2021年3月鞍钢集团公司总医院消化科接诊的炎症性肠病患者140例(活动期78例,缓解期62例)以及同时间段内至本院进行体检的健康者60例的资料进行回顾性分析。对比炎症性肠病活动期患者、炎症性肠病缓解期患者、健康体检者的血清IL-6、sICAM-1、chemerin、交感神经功能、迷走神经功能。分析血清IL-6、sICAM-1、chemerin与交感神经功能、迷走神经功能之间的相关性。分析IL-6、sICAM-1、chemerin对炎症性肠病的诊断价值。结果:炎症性肠病活动期患者、炎症性肠病缓解期患者、健康体检者的血清IL-6、sICAM-1、chemerin、交感及迷走神经功能比较,差异均有统计学意义(P<0.05)。血清IL-6、sICAM-1、chemerin与卧位立位血压差之间均呈正相关,与握力试验血压差和卧位立位心率差之间均呈负相关(P<0.05)。利用血清IL-6、sICAM-1、chemerin对炎症性肠病患者进行诊断,最佳截断值分别为38.89 pg/mL、154.03 ng/mL、112.21μg/L,约登指数分别为0.271、0.350、0.471。结论:炎症性肠病的发病以及病情波动与人体的免疫紊乱、自主神经功能紊乱、脂质代谢紊乱等具有一定的关系,利用IL-6、sICAM-1、chemerin对炎症性肠病患者进行监测可能具有一定的意义,但尚需要更多的研究进行分析。
Objective:To explore the changes and significance of serum interleukin-6(IL-6),soluble intercellular adhesion molecule-1(sICAM-1)and adipocytokines(chemerin)in patients with inflammatory bowel disease.Method:The data of 140 patients with inflammatory bowel disease(78 in active period and 62 in remission period)admitted to the gastroenterology department of Ansteel Group General Hospital from February 2017 to March 2021 and 60 healthy peoples who came to our hospital for physical examination within the same time period were selected for retrospective analysis.The serum IL-6,sICAM-1,chemerin,sympathetic nerve function and vagus nerve function of patients with active inflammatory bowel disease,patients with remission of inflammatory bowel disease and healthy subjects were compared.The correlation between serum IL-6,sICAM-1,chemerin and sympathetic nerve function and vagus nerve function were analyzed.The diagnostic value of IL-6,sICAM-1,chemerin for inflammatory bowel disease were analyzed.Result:There were significant differences in serum IL-6,sICAM-1,chemerin,sympathetic,and vagus nerve function in patients with active inflammatory bowel disease,patients in remission of inflammatory bowel disease and healthy subjects(P<0.05).Serum IL-6,sICAM-1,chemerin were positively correlated with the difference in supine and standing blood pressure,and were negatively correlated with the grip strength test and the difference in supine and standing heart rate(P<0.05).Serum IL-6,sICAM-1 and chemerin were used to diagnose patients with inflammatory bowel disease,the best cut-off values were 38.89 pg/mL,154.03 ng/mL,112.21μg/L,and the Youden index were 0.271 and 0.350,0.471.Conclusion:The incidence and fluctuations of inflammatory bowel disease have a certain relationship with the body’s immune disorder,autonomic nervous function disorder,lipid metabolism disorder,etc,it is possible to use IL-6,sICAM-1,chemerin to monitor patients with inflammatory bowel disease,it has a certain meaning,but more research is needed for analysis.
作者
刘春辉
刘兆润
董丽
丁宁
LIU Chunhui;LIU Zhaorun;DONG Li;DING Ning(Ansteel Group General Hospital,Anshan 114002,China;不详)
出处
《中国医学创新》
CAS
2022年第5期119-123,共5页
Medical Innovation of China
关键词
炎症性肠病
肠道黏膜
免疫系统
自主神经紊乱
血清学指标
菌群失衡
Inflammatory bowel disease
Intestinal mucosa
Immune system
Autonomic disorders
Serological indicators
Flora imbalance
