摘要
目的分析伏立康唑对免疫抑制剂的浓度及引起的临床不良结局,为临床安全合理应用提供参考。方法通过查阅国内外文献总结有关伏立康唑对免疫抑制剂影响以及各国指南推荐的联合用药剂量。结果伏立康唑对免疫抑制剂的影响个体差异很大,药品说明书及指南中的推荐剂量并不适合所有患者。结论伏立康唑和免疫抑制剂合用需要根据血药浓度和肝药酶基因多态性进行个体化给药。
Objective To review the concentrations of immunosuppressants when used with voriconazole and the adverse clinical outcomes caused by voriconazole in order to provide references for safe and rational clinical use of this drug. Methods Domestic and foreign literature about the effect of voriconazole on immunosuppressants as well as the combined dosage recommended in guidelines in different countries were reviewed. Results The effect of voriconazole on immunosuppressants varied widely from individual to individual. The dosage of voriconazole recommended in different instructions and guidelines was not applicable to each patient. Conclusion The combination of voriconazole and immunosuppressants requires individualized administration according to the blood concentration and genetic polymorphisms of enzymes in liver drugs.
作者
曹鑫
崔向丽
CAO Xin;CUI Xiangli(Department of Pharmacy,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;College of Pharmaceutical Sciences,Capital Medical University,Beijing 100069,China;Department of Pharmacy,Hospital of Beijing Foreign Studies University,Beijing 100081,China)
出处
《中国药物警戒》
2022年第2期193-195,共3页
Chinese Journal of Pharmacovigilance
基金
国家卫生健康委员会卫生技术评估重点实验室2019年度开放基金(FH019-02)
北京市医院管理中心2020年培育项目(PG2020002)。
关键词
伏立康唑
免疫抑制剂
血药浓度
药品不良反应
voriconazole
immunosuppressant
blood concentration
adverse drug reaction
