摘要
整合素是一类跨膜糖蛋白,介导细胞与细胞、细胞与细胞外间质之间的黏附及信号传导,调节细胞的黏附、迁移、增殖和凋亡等功能,在新生血管内皮细胞及多种恶性肿瘤细胞表面高表达。基于精氨酸⁃甘氨酸⁃天冬氨酸(arginine⁃glycine⁃aspartate,RGD)结构的多肽能够与整合素α_(V)β_(3)等亚型特异结合,通过单光子发射计算机断层成像或正电子发射断层成像,无创、在体显示肿瘤的浸润转移特性以及评估血管新生情况等,具有较大的临床应用价值。基于国际、国内相关临床研究最新进展,本专家共识旨在建立整合素RGD受体显像临床应用的指导原则。
Integrin is a group of transmembrane glycoprotein that mediates cell⁃cell adhesion and signal transduction.It regulates cell adhesion,migration,proliferation,apoptosis and other functions.It is highly ex⁃pressed on the surface of neovascular endothelial cells and a variety of malignant tumor cells.The peptides with⁃arginine⁃glycine⁃aspartate(RGD)motif can specifically bind to multiplesubtypes of integrin includingα_(V)β_(3).When labeled with radionuclides for single photon emission tomography(SPECT)or positron emission tomo⁃graphy(PET),the RGD⁃based peptides can non⁃invasively reveal the tumor characteristics,including invasion and metastasis,as well as evaluate angiogenesis in vivo.These methods have shown strong value in clinical application.Based on the home⁃and⁃abroad progress in relevant clinical research,this expert consensus aims to establish principles for clinical application of RGD⁃based peptides to integrin imaging.
作者
中华医学会核医学分会
中国生物物理学会分子影像学分会
朱朝晖
李思进
王凡
Chinese Society of Nuclear Medicine;Chinese Society of Molecular Imaging in Chinese Biophysical Society;ZHU Zhaohui;LI Sijin;WANG Fan(不详;Department of Nuclear Medicine,Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Nuclear Medicine,First Hospital of Shanxi Medical University,Taiyuan 030001,China;Medical Isotopes Research Center,Peking University,Beijing 100191,China)
出处
《协和医学杂志》
CSCD
2022年第2期227-234,共8页
Medical Journal of Peking Union Medical College Hospital
基金
国家自然科学基金(81871392)
中国医学科学院医学与健康科技创新工程(2021⁃I2M⁃1⁃016)
首都卫生发展科研专项(2018⁃1⁃4011)
广州实验室应急攻关项目(EPKG21⁃16)
中国医学科学院临床转化基金(2019XK320032)。
关键词
整合素
受体显像
精氨酸⁃甘氨酸⁃天冬氨酸多肽
临床应用专家共识
integrin
receptor imaging
arginine⁃glycine⁃aspartate⁃based peptides
expert consensus on clinical application
