摘要
酒精性肝病(ALD)是由于长期或大量饮酒所致的肝脏疾病。初期通常表现为酒精性脂肪肝,如不加以有效治疗,可发展成酒精性肝炎、肝纤维化和肝硬化,严重的可发展为肝癌。近年研究发现,黄酮类化合物具有多种药理活性,在改善脂质代谢、抗炎、抗氧化和抗肿瘤等方面作用显著,能够有效减轻酒精性肝损伤,有望开发为治疗ALD的新型药物。本文对近年来天然黄酮类化合物对ALD的治疗作用及相关机制研究进展进行综述,为基于黄酮类化合物治疗ALD相关创新药物的研究与开发提供参考和依据。
Alcoholic liver disease(ALD)is a liver disease caused by long-term or heavy drinking.In the early stage,ALD is usually revealed as alcoholic fatty liver disease.If not treated effectively,it can eventually progress to alcoholic hepatitis,fibrosis,and cirrhosis,or hepatocellular carcinoma.Recent studies found that flavonoids showed many pharmacological activities with significant effect on improving the lipid metabolism,anti-inflammation,anti-oxidation,and anti-tumor.Flavonoids can effectively alleviate the alcoholic liver injury,and are expected to be the new therapeutic agents in ALD treatment.We reviewed the recent research progress in natural flavonoids for ALD and their mechanism to provide reference for the research and development of flavonoids-based innovative drugs for ALD.
作者
沈佳妍
徐婧淇
刘淼
王丹
陈倩
王涛
刘梦扬
SHEN Jia-yan;XU Jing-qi;LIU Miao;WANG Dan;CHEN Qian;WANG Tao;LIU Meng-yang(Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300190)
出处
《中南药学》
CAS
2022年第2期371-381,共11页
Central South Pharmacy
基金
国家自然科学基金项目(No.82004062)。
关键词
酒精性肝病
天然黄酮类化合物
保护机制
alcoholic liver disease
natural flavonoid
protection mechanism
