摘要
目的:讨红细胞分布宽度、胱抑素C与冠状动脉药物洗脱支架置入术后发生支架内再狭窄的关系。方法 :选取2018年1月至2019年12月,就诊于北京朝阳医院或盛京医院诊断为不稳定性心绞痛并行冠状动脉药物洗脱支架置入手术的患者共511例,根据随访复查冠状动脉造影的结果分为支架内再狭窄组(105例)及对照组(406例)。所有患者空腹肘静脉采血进行相关化验检查。结果 :两组患者,支架内再狭窄组红细胞分布宽度、胱抑素C及hs-CRP高于对照组,支架内再狭窄组平均支架直径小于对照组。多元Logistic回归分析提示红细胞分布宽度(OR=4.014)、胱抑素C(OR=5.252)及hs-CRP的升高(OR=7.210)是支架内再狭窄发生的危险因素。绘制ROC曲线,红细胞分布宽度、hs-CRP、胱抑素C三者的ROC曲线下面积分布为0.742、0.736、0.718。结论 :红细胞分布宽度及胱抑素C是发生支架内再狭窄的危险因素,其预测支架内再狭窄的价值与hs-CRP相似。
Objective: To discuss the relationship between red blood cell distribution width, cystain C and in-stent restenosis. Methods: 511 unstable angina patients who received percutaneous coronary intervention and coronary angiography in Beijing Chaoyang hospital or Shengjing hospital between 2018-01 and 2019-12. According to the results of follow-up coronary angiography, patients were divided into 2 groups:in-stent restenosis group(105) and control group(406). All patients received appropriate laboratory tests and medical attention. Results: Red blood cell distribution width, cystatin C, hs-CRP in in-stent restenosis group were higher than control group. Stent diameter in in-stent restenosis group was smaller than control group.Multivariate Logistic regression analysis showed that increased red blood cell distribution width(OR= 4.014),cystatin C(OR = 5.252), hs-CRP(OR = 7.210) were risk factors for In-stent restenosis. The area distribution under ROC curve of red blood cell width, hs-CRP, and cystatin C were 0.742, 0.736, 0.718 respectively.Conclusions: Red blood cell distribution width and cystatin C were risk factors of the occurrence of in-stent restenosis similar to hs-CRP.
作者
刘晔
刘丽凤
陈洁
杨新春
LIU Ye;LIU Lifeng;CHEN Jie;YANG Xinchun(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)
出处
《心肺血管病杂志》
CAS
2022年第1期31-34,88,共5页
Journal of Cardiovascular and Pulmonary Diseases
关键词
红细胞分布宽度
胱抑素C
超敏C反应蛋白
支架内再狭窄
Red blood cell distribution width
Cystatin C
Hypersensitive C-reactive protein
In-stent restenosis
