摘要
目的:观察六味地黄丸治疗慢性肾功能衰竭(chronic renal failure, CRF)患者心肾不交型不寐的临床疗效,并分析其对血清三碘甲状腺原氨酸(triiodothyronine, T3)、四碘甲状腺原氨酸(tetraiodothyronine, T4)和多巴胺(dopamine, DA)水平的影响。方法:120例心肾不交型不寐CRF患者按照随机数字表法分为对照组和观察组各60例。对照组给予艾司唑仑片,观察组在对照组治疗基础上给予六味地黄丸,两组均治疗6个月。治疗后,比较两组患者睡眠质量、中医证候评分、中医临床疗效、艾司唑仑片用量及血清T3、T4、DA水平。结果:治疗后,观察组患者PSQI总分、各因子评分、中医证候积分及血清T3、T4、DA水平均低于对照组,且观察组患者治疗第1个月、3个月和6个月艾司唑仑片平均每日用量呈逐渐下降趋势,治疗第3个月和6个月用量明显低于同期对照组(P<0.05)。观察组临床治疗有效率为91.67%,明显高于对照组的78.33%(P<0.05)。两组患者不良事件发生率比较,差异无统计学意义(P>0.05)。结论:六味地黄丸治疗CRF心肾不交型不寐患者临床疗效确切,可明显改善患者中医临床症状,调节甲状腺激素和DA水平,减少艾司唑仑片用药剂量,降低药物依赖性,具有较高的安全性。
Objective: To observe the clinical efficacy of Liuwei Dihuang Pills in the treatment of chronic renal failure(CRF) patients with heart-kidney incompatibility insomnia, and analyze its effect on serum triiodothyronine(T3),tetraiodothyronine(T4),and dopamine(DA) levels.Methods: 120 CRF patients with insomnia with heart-kidney incompatibility were divided into a control group and an observation group with 60 cases each according to the random number table method.The control group was given estazolam tablets, and the observation group was given Liuwei Dihuang Pills on the basis of the treatment of the control group, both groups were treated for 6 months.After treatment, the sleep quality, TCM syndrome score, TCM clinical efficacy, the dosage of estazolam tablets, and serum T3,T4,and DA levels were compared between the two groups.Results: After the treatment, the total PSQI score, the scores of various factors, the TCM syndrome score, and the serum T3,T4 and DA levels of the observation group were lower than those of the control group.And the average daily dosage of estazolam tablets in the 1 st month, 3 rd months, and 6 th months of treatment in the observation group showed a gradual downward trend, and the dosage in the 3 rd and 6 th months of treatment was significantly lower than that in the control group(P<0.05).The effective rate of clinical treatment in the observation group was 91.67%,which was significantly higher than that in the control group, 78.33%(P<0.05).There was no significant difference in the incidence of adverse events between the two groups(P>0.05).Conclusion: Liuwei Dihuang Pill has a definite clinical effect on insomnia patients with CRF heart-kidney incompatibility.It can significantly improve the patients′ clinical TCM symptoms, adjust the level of thyroid hormone and DA,reduce the dosage of estazolam tablets and drug dependence, and has high safety.
作者
罗洁
束永兵
LUO Jie;SHU Yongbing(Liuan City Hospital of Traditional Chinese Medicine,Liuan Anhui China 237006)
出处
《中医学报》
CAS
2022年第4期877-882,共6页
Acta Chinese Medicine
基金
安徽省教育厅2018年度高校科学研究项目(KJ2018C0538)。
关键词
慢性肾功能衰竭
失眠症
不寐
心肾不交证
六味地黄丸
甲状腺激素
多巴胺
chronic renal failure
insomnia
Bu Mei
Heart-Kidney incompatibility
Liuwei Dihuang Pill
thyroid hormone
dopamine
