Engineered T cells and their therapeutic applications in autoimmune diseases 被引量：4

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摘要 Chimeric antigen receptor T cells(CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficiency, CAR-T cells show considerable potential in the treatment of autoimmune diseases.Furthermore, regulatory T cells(Treg), a subset of CD4 T cells exhibiting immunosuppressive functions,have attracted increasing attention regarding CARTreg cell production. In this review, we report on recent developments in preclinical and clinical studies on CAR-T cells in autoimmune diseases and provide an outlook on opportunities and challenges of CAR-T application in such diseases.

作者 Lei Bao Xiao-Chen Bo Huai-Wen Cao Chen Qian Zeng Wang Bin Li

机构地区 Department of Immunology and Microbiology

出处《Zoological Research》 SCIE CAS CSCD 2022年第2期150-165,共16页 动物学研究（英文）

基金 supported by the National Natural Science Foundation of China(81830051,31961133011,32130041) National Key R&D Program of China(2019YFA09006100) Shanghai Academic Research Leader(16XD1403800) Innovative Research Team of High-Level Local Universities in Shanghai Shanghai Collaborative Innovation Center of Cellular Homeostasis Regulation and Human Diseases。

关键词 Chimeric antigen receptor T cells Cell immunotherapy Autoimmune diseases

分类号 R593.2 [医药卫生—内科学]

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