摘要
目的探讨艾司奥美拉唑、奥曲肽与血凝酶三联治疗急性上消化道出血(AUGIH)的疗效及对凝血功能的影响。方法选取2019年1月—2021年6月在广州市第十二人民医院确诊的84例AUGIH患者,随机分为2组。对照组(n=42)采用艾司奥美拉唑治疗,观察组(n=42)采用艾司奥美拉唑、奥曲肽与血凝酶三联治疗,均持续治疗5 d,对比2组的疗效。结果观察组治疗有效率(95.24%)明显高于对照组(80.95%)(P<0.05)。治疗后的RBC、Hb、PLT和FIB水平均有所上升,WBC、D-二聚体、APTT和PT水平均有所下降,且观察组变化更明显(P<0.05)。观察组止血时间和再出血率明显少于对照组(P<0.05)。2组不良反应发生率无统计学差异(P>0.05)。结论艾司奥美拉唑、奥曲肽与血凝酶三联治疗可以明显提高AUGIH患者的临床疗效,改善凝血功能。
Objective To investigate the efficacy of esmeprazole,octreotide and hemagglutinase in the treatment of acute upper gastrointestinal bleeding(AUGIH)and its effect on coagulation function.Methods 84 patients with AUGIH diagnosed in our hospital from January 2019 to June 2021 were randomly divided into two groups.The control group(n=42)was treated with esmeprazole,and the observation group(n=42)was treated with esmeprazole,octreotide and hemagglutinase for 5 days.The curative effects of the two groups were compared.Results The effective rate of the observation group(95.24%)was significantly higher than that of the control group(80.95%)(P<0.05).After treatment,the levels of RBC,Hb,PLT and Fib in AUGIH patients in the two groups increased,and the levels of WBC,D-Dimer,APTT and PT decreased(P<0.05),and the changes in the observation group were more obvious(P<0.05).The hemostatic time and rebleeding rate in the observation group were significantly less than those in the control group(P<0.05).There was no significant difference in the incidence of total adverse reactions between the two groups(P>0.05).Conclusion The triple therapy of esmeprazole,octreotide and hemagglutinase can significantly improve the clinical efficacy and coagulation function of patients with AUGIH.
作者
伍淑英
温凌
宋慧东
Wu Shuying;Wen Ling;Song Huidong(The Twelfth People's Hospital of Guangzhou City,Guangzhou,Guangdong 510000)
出处
《基层医学论坛》
2022年第7期49-51,共3页
The Medical Forum
关键词
急性上消化道出血
艾司奥美拉唑
奥曲肽
血凝酶
凝血功能
Acute upper gastrointestinal bleeding
Esmeprazole
Octreotide
Hemocoagulase
Coagulation function
