摘要
分别以刚性的明胶、柔性的聚(甲基丙烯酸-2-羟基乙酯-co-丙烯酸)为第一网络和第二网络,采用加热-冷却-光聚合法制备了物理-化学杂化交联的明胶/聚(甲基丙烯酸-2-羟基乙酯-co-丙烯酸)双网络水凝胶.采用傅里叶红外光谱表征了水凝胶双网络之间的氢键相互作用,扫描电镜表征了双网络凝胶的形貌特征,万能拉伸试验机测试了水凝胶的机械性能,以及称重法计算了水凝胶的溶胀能力.研究结果表明,该凝胶不仅具有高力学强度(拉伸应力/应变:1.23 MPa/682.17%)、快速自恢复能力(常温休息60 s,能量耗散/峰值应力的恢复率:77.47%/99.97%)、抗疲劳特性(经过10次连续的加载-卸载循环后,峰值应力保留率:93.75%),还具有优良的抗溶胀特性(溶胀44 h后达到溶胀平衡,溶胀率为0.63).该研究结果为制备具有抗溶胀特性的明胶基水凝胶提供了新思路,有望推动水凝胶在生物医学工程领域的应用.
A physical-chemical crosslinked gelatin/poly(2-hydroxyethyl methacrylate-co-acrylic acid)(gelatin/p(HEMA-co-AA))double network(DN)hydrogel was prepare via heating-cooling-photopolymerization method.The resultant gelatin/p(HEMA-co-AA)DN hydrogel was consisted of first rigid gelatin network and the second flexible p(HEMA-co-AA)network.The chemical structure and physical property of hydrogel were investigated by FTIR,SEM,and universal tensile testing machine.The result indicated the hydrogel exhibited high toughness(tensile stress/strain of 1.23 MPa/682.17%),rapid self-recovery(energy dissipation/peak stress recovery efficiency of 77.47%/99.97%after resting 60 s at room temperature),excellent fatigue resistance(the peak stress retention rate of 93.75%after 10 consecutive loading-unloading cycles)and anti-swelling property(swelling ratio of 0.63).This work provides a simple way to construct gelatin-based hydrogel with high toughness,fast self-recovery and anti-swelling property,which is expected to promote the application of hydrogel in biomedical engineering.
作者
伍绍吉
袁尘瑜
汤建新
汤力
WU Shaoji;YUAN Chenyu;TANG Jianxin;TANG Li(College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China)
出处
《湘潭大学学报（自然科学版）》
CAS
2022年第1期31-40,共10页
Journal of Xiangtan University(Natural Science Edition)
基金
国家自然科学基金面上项目(51774128)。
关键词
双网络水凝胶
高强度
快速自恢复
抗溶胀
double network hydrogel
high toughness
rapid self-recovery
anti-swelling
