摘要
【目的】观察三金排石颗粒对气滞血瘀型输尿管结石(石淋)患者行输尿管镜下钬激光碎石术(URSHL)后排石疗效的影响,并初步探讨其作用机制。【方法】将80例气滞血瘀型输尿管结石(石淋)患者随机分为治疗组和对照组,每组各40例。2组患者均给予URSHL治疗,对照组予以术后常规治疗,治疗组在对照组的基础上于术后1~7 d和15~22 d给予服用三金排石颗粒治疗。观察2组患者治疗1周后疼痛视觉模拟量表(VAS)评分的变化情况,并于治疗4周后评价2组患者的排石疗效和安全性。【结果】(1)疼痛情况方面:治疗1周后,2组患者的疼痛VAS评分均较治疗前明显降低(P<0.01),且治疗组的降低作用明显优于对照组,差异有统计学意义(P<0.01)。(2)排石疗效方面:治疗4周后,治疗组的治愈率、改善率和总有效率分别为72.5%(29/40)、20.0%(8/40)和92.5%(37/40),对照组分别为55.0%(22/40)、10.0%(4/40)和65.0%(26/40),组间比较,治疗组的排石疗效明显优于对照组,差异有统计学意义(P<0.01)。(3)安全性方面:治疗期间,2组患者均未出现明显的不良反应及相关副作用。【结论】在输尿管镜下钬激光碎石术后应用三金排石颗粒治疗气滞血瘀型输尿管结石(石淋)患者疗效确切,可以有效改善患者临床症状,提高患者的结石排出率和排净率。
Objective To observe the influence of Sanjin Paishi Granules on the lithagogue effect for ureteral calculus patients with qi-stagnation and blood-stasis type after ureteroscopic holmium laser lithotripsy(URSHL),and to explore its therapeutic mechanism.Methods Eighty cases of ureteral calculus with qi stagnation and blood stasis syndrome type were randomly divided into treatment group and control group,with 40 cases in each group.Both groups were treated with URSHL,and additionally,the control group was given conventional postoperative treatment while the treatment group was given Sanjin Paishi Granules orally on postoperative day 1 to 7 and on postoperative day 15 to 22 based on conventional postoperative treatment.The visual analogue scale(VAS)scores of pain in the two groups were observed after one week of treatment,and the lithagogue effect and clinical safety in the two groups were evaluated after 4 weeks of treatment.Results(1)After one week of treatment,pain VAS scores in the two groups were significantly decreased compared with those before treatment(P<0.01),and the effect on lowering pain VAS scores in the treatment group was significantly superior to that in the control group,the differences being statistically significant(P<0.01).(2)In terms of the efficacy of stone removal,the cure rate,improvement rate and total effective rate after 4 weeks of treatment in the treatment group were 72.5%(29/40),20.0%(8/40)and 92.5%(37/40),respectively,and were 55.0%(22/40),10.0%(4/40)and 65.0%(26/40)in the control group,respectively.The intergroup comparison showed that the lithagogue effect in the treatment group was significantly superior to that in the control group,the difference being statistically significant(P<0.01).(3)During the treatment,there were no obvious adverse reactions or side effects in the two groups.Conclusion The application of Sanjin Paishi Granules after URSHL exerts certain effect in treating patients with ureteral calculus(urolithiasis)differentiated as qi-stagnation and blood-stasis type,which can effectively relieve the clinical symptoms and increase the stone discharge rate and lithagogue rate of the patients.
作者
梁柏庆
蔡泽锋
赵冬
LIANG Bai-Qing;CAI Ze-Feng;ZHAO Dong(Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;Guangdong Second Traditional Chinese Medicine Hospital,Guangzhou 510095 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2022年第4期782-786,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药局科研项目(编号:20211027)。
关键词
输尿管镜下钬激光碎石术
三金排石颗粒
气血瘀滞型
输尿管结石
石淋
ureteroscopic holmium laser lithotripsy(URSHL)
Sanjin Paishi Granules
qi-stagnation and blood-stasis type
ureteral calculus
urolithiasis
