摘要
目的:基于数据挖掘技术研究中医药治疗梅尼埃病用药规律。方法:运用计算机从中国知网数据库(CNKI)、万方数据库(WF)和维普数据库(VIP)搜索自建库以来有关于运用中医药治疗梅尼埃病的文献,对符合纳入标准的文献进行预处理,运用Excel2013进行频数分析;运用SPSS Modeler18进行关联规则中Apriori算法分析;运用SPSS Statistics 25次进行聚类分析。结果:本研究共纳入文献133篇,方剂146首,药物总数192味,药物出现总频数为1702次。高频次梅尼埃病证型分别为:脾虚痰湿证、风痰证、胆郁痰扰证、肝阳上亢证、痰瘀互结证。对药物频数≥25的功效总结分别为:化痰止咳平喘、利水渗湿、补虚等;高频药物归经分别为:肺、肝、脾等;高频药物药性分别为:温、寒、平等;高频药物药味分别为:苦、甘、辛等。核心药物为:半夏、白术、茯苓、天麻等。主要组方为泽泻汤、半夏白术天麻汤、镇肝息风汤、小柴胡汤。结论:本研究通过数据挖掘对中药治疗梅尼埃疾病整理,发现其治疗以平肝健脾为主,佐以理气活血,清热开窍,补虚安神等。
Objective:To study the medication rules of traditional Chinese medicine in treating Meniere’s disease based on data analysis.Methods:Since establishment of the“CNKI”,“WF”,“VIP”,literatures on the treatment of Meniere syndrome with traditional Chinses medicine were selected and preprocessed.Memory preprocessing in accordance with inclusion criteria.Then,EXCLE 2010,SPSS Statistics(ver.25)and SPSS Modeler(ver.18.0)were adopted respectively for frequency analysis,cluster analysis and association rules analysis.Results:A total of 133 references were included in this study,146 prescriptions,192kinds of drugs,and the total frequency of drugs was 1702.The high frequency Meniere syndrome types were:spleen deficiency and phlegm dampness syndrome,wind phlegm syndrome,gallbladder depression and phlegm disturbance syndrome,hyperactivity of liver yang syndrome,phlegm and blood stasis syndrome.The efficacy of drug frequency≥25 were summarized as follows:antiasthmatic drugs for relieving phlegm and relieving cough,diuresis-removing dampness,Tonic drugs,etc.High frequency meridian of drugs are:lung,liver,spleen,etc.High frequency drug properties are:temperature,cold,flat etc.High frequency drug taste:bitter,sweet,pungent,etc.Core drugs:Pinellia,Atractylodes,Poria,Gastrodia,etc.The main prescriptions werealisma soup,Banxia Baizhu Tianma Decoction,Zhengan Xifeng Decoction and Xiaochaihu Decoction.Conclusion:In this study,data was analyzed to sort out the treatment of Meniere’s disease by traditional Chinese medicine.It was found that the treatment of Meniere’s disease was mainly to calm the liver and strengthen the spleen,supplemented by regulating qi and activating blood,clearing heat and opening orifices,tonifying deficiency and tranquilizing mind.
作者
张会杰
尹德辉
苏妙芳
翟欣然
陈桂敏
ZHANG Hui-jie;YIN De-hui;SU Miao-fang;ZHAI Xin-ran;CHEN Gui-min(Basic Medical College of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Hainan Medical College,Haikou 571101,China)
出处
《海南医学院学报》
CAS
2022年第7期539-543,549,共6页
Journal of Hainan Medical University
基金
海南省自然科学基金项目(2019RC231)
国家自然科学基金项目(81660786)。
关键词
梅尼埃病
用药规律
眩晕
数据挖掘
Meniere’s disease
Medication rule
Vertigo
Medication law
Data analysis
