摘要
雄激素与青春期女性生殖发育的生理病理密切相关,对卵巢卵泡发育具有重要影响。雄激素可以直接通过雄激素受体发挥作用,刺激原始卵泡发育启动;也可作为雌激素底物,转化为雌激素后间接发挥作用。由于性腺轴不稳定,青春期女性与多囊卵巢综合征(PCOS)临床表现具有一定重合。适量雄激素可促进卵巢发育,雄激素缺乏不利于卵巢正常发育,雄激素过多则会导致PCOS,肾上腺网状带合成的雄激素也会对卵巢发育产生影响。对雄激素与卵巢卵泡发育关系的进一步研究,有助于诊断青春期PCOS,也可为具有窦前卵泡的不孕患者提供新的治疗方向。
Androrogens is closely related to the physiophysiology of female reproductive development at puberty and has an important influence on ovarian follicle development.Androgen can function directly through the androgen receptor to stimulate the initiation of primary follicular development.It can also act as an estrogen substrate and function indirectly after conversion into estrogen.The clinical manifestations of adolescent women may coincide with polycystic ovary syndrome(PCOS)due to gonadal axis instability.The moderate amount of androgen promotes ovarian development,while the androgen deficiency is not conducive to normal ovarian development,and the excessive androgen can lead to PCOS.Androgen synthesized by adrenal reticular zone also has an effect on ovarian development.Further studies of the relationship between androgens and ovarian follicle development can contribute to the diagnosis of pubertal PCOS,and also provide new therapeutic directions for infertile patients with presinusoidal follicles.
作者
张祎俐
石鸿娇
赵彤
崔岚巍
ZHANG Yili;SHI Hongjiao;ZHAO Tong;CUI Lanwei(Department of Pediatrics,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《医学综述》
CAS
2022年第5期871-875,共5页
Medical Recapitulate
基金
国家重点研发计划重大慢性非传染性疾病防控研究项目(2016YFC1305301)。
