摘要
结核病(TB)是严重危害儿童健康的重要疾病,由于儿童TB的特殊性,其在诊断和治疗方面存在诸多问题:儿童TB临床表现和症状缺乏特异性、临床医师对疾病的重视程度不够、病原学检测标本难以获取、现有诊断方法的敏感性不足、缺乏儿童友好型抗结核药物、缺乏儿童抗结核药物药代动力学/药效学研究数据和基于儿童数据的抗结核治疗方案等。现就上述问题及其应对策略和展望进行总结。
Tuberculosis is still a big threat to children.However,due to the particularity of tuberculosis in children,there are many problems in diagnosis and treatment,such as the clinical manifestations and symptoms of children are not specific,clinicians do not pay enough attention to the disease,the specimen for pathogen detection is difficult to obtain,the sensitivity of existing diagnostic methods is not enough,lack of child-friendly anti-tuberculosis drugs,pharmacokinetic/pharmacodynamics researches of anti-tuberculosis drugs in children and anti-tuberculosis treatment regimens based on children studies.This paper summarizes the above-mentioned problems and their countermeasures and prospects.
作者
刘芳
焦伟伟
申阿东
Liu Fang;Jiao Weiwei;Shen Adong(Beijing Key Laboratory of Pediatric Respiratory Infection Diseases,Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,National Key Discipline of Pediatrics(Capital Medical University),Beijing Pediatric Research Institute,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2022年第7期486-489,共4页
Chinese Journal of Applied Clinical Pediatrics
关键词
结核病
儿童
诊断
治疗
进展
Tuberculosis
Child
Diagnosis
Treatment
Progress
