摘要
目的探究恩替卡韦联合微生态制剂治疗乙肝肝硬化的临床效果及对患者肝功能、肝纤维化指标的影响。方法选取我院收治的120例乙肝肝硬化患者,采取随机数字表法将其分为对照组(60例,恩替卡韦)与观察组(60例,恩替卡韦+微生态制剂)。比较两组的治疗效果、临床症状、肝功能指标、肝纤维化指标及腹部彩超结果。结果观察组的治疗总有效率明显高于对照组(P<0.05)。治疗后,两组的腹胀、乏力、厌食发生率均降低,且观察组明显低于对照组(P<0.05)。治疗后,两组的AST、ALT、TBIL水平均降低,且观察组明显低于对照组(P<0.05)。治疗后,两组的HA、LN、Ⅳ-C、PC-Ⅲ水平均降低,且观察组明显低于对照组(P<0.05)。治疗后,两组的脾脏厚度、门静脉内径均缩短,且观察组明显短于对照组(P<0.05)。两组在用药期间均未出现明显的不良反应。结论恩替卡韦联合微生态制剂治疗乙肝肝硬化的临床效果显著,可有效缓解临床症状及体征,同时可显著改善肝功能及肝纤维化指标,腹部彩超表现更好。
Objective To explore the clinical effect of entecavir combined with probiotics in the treatment of hepatitis B cirrhosis and its influences on liver function and liver fibrosis indexes of patients.Methods A total of 120 patients with hepatitis B cirrhosis who were treated in our hospital were selected and divided into control group(60 cases,entecavir)and observation group(60 cases,entecavir+probiotics)by random number table method.The therapeutic effect,clinical symptoms,liver function indexes,liver fibrosis indexes and abdominal color Doppler ultrasound results were compared between the two groups.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the incidences of abdominal distension,fatigue and anorexia in both groups decreased,and those in the observation group were significantly lower than the control group(P<0.05).After treatment,the levels of AST,ALT and TBIL in the two groups decreased,and those in the observation group were significantly lower than the control group(P<0.05).After treatment,the levels of HA,LN,Ⅳ-C and PC-Ⅲin both groups decreased,and those in the observation group were significantly lower than the control group(P<0.05).After treatment,the thickness of the spleen and the diameter of the portal vein in the two groups shortened,and those in the observation group were significantly shorter than the control group(P<0.05).There were no obvious adverse reactions in both groups at the treatment period.Conclusion Entecavir combined with probiotics in the treatment of hepatitis B cirrhosis has a significant clinical effect,which can effectively relieve clinical symptoms and signs,and at the same time can significantly improve liver function and liver fibrosis indexes,and abdominal color Doppler ultrasound performance is better.
作者
赵伟锋
王伟
ZHAO Weifeng;WANG Wei(Gastroenterology Department,Tongchuan Mining Bureau Central Hospital Affiliated to Shaanxi University of Chinese Medicine,Tongchuan 727000,China;Hepatobiliary Surgery Department,Tongchuan Mining Bureau Central Hospital Affiliated to Shaanxi University of Chinese Medicine,Tongchuan 727000,China)
出处
《临床医学研究与实践》
2022年第12期44-47,共4页
Clinical Research and Practice
关键词
恩替卡韦
微生态制剂
乙肝肝硬化
肝纤维化
腹部彩超
entecavir
probiotics
hepatitis B cirrhosis
liver fibrosis
abdominal color Doppler ultrasound
