摘要
近年来膀胱癌的治疗在世界范围内取得了很大进展,包括传统的手术切除、化疗和放疗以及免疫治疗,然而其潜在的分子机制和关键途径仍不清楚。随着基因测序技术的进步,长链非编码RNA(lncRNA)已被证明以不同的分子机制在多种肿瘤组织中显示致癌基因的作用。竞争性内源RNA(ceRNA)假说是一种RNA之间相互作用的新机制,具有微小RNA(miRNA)的结合位点的lncRNA,可行使miRNA海绵作用吸附于miRNA,进而解除miRNA对其靶基因的抑制作用,升高靶基因的表达水平。本文就lncRNA作为ceRNA参与膀胱癌进展的研究进展做一综述。
In recent years,great progress has been made in the treatment of bladder cancer,including traditional surgical resection,chemotherapy and radiotherapy and immunotherapy.However,its potential molecular mechanisms and key pathways remain unclear.With the progress of sequencing gene technology,long non-coding RNA(lncRNA)has been proved to show the role of oncogenes in a variety of tumor tissues by different molecular mechanisms.The competing endogenous RNA(ceRNA)hypothesis is a new mechanism of interaction between RNAs.As competing for miRNA binding sites with endogenous miRNAs,lncRNA can be regarded as a sponge to adsorb miRNA,leading to relieve the inhibition of miRNA on its target gene and increase the expression level of target gene.This article reviews the latest research progress on the involvement of lncRNA as ceRNA in the progression of bladder cancer.
作者
杜元程
孙美红
杨栋嵛
乔梁
DU Yuan-cheng;SUN Mei-hong;YANG Dong-yu;QIAO Liang(Weifang Medical University,Weifang,Shandong 261000,China;不详)
出处
《中国临床研究》
CAS
2022年第4期560-562,567,共4页
Chinese Journal of Clinical Research
