摘要
目的:探讨瑞巴派特、奥美拉唑、生长抑素三联疗法治疗胃溃疡出血患者的效果。方法:回顾性分析2019年4月至2020年4月该院收治的150例胃溃疡出血患者的临床资料,根据治疗方法不同将患者分为对照组和观察组,各75例。对照组给予口服奥美拉唑肠溶片和静脉滴注生长抑素治疗,观察组在其基础上加用瑞巴派特片治疗。比较两组临床疗效,腹痛、头晕、恶心、便血/呕血等症状消失时间,治疗前后血清白细胞介素-8(IL-8)水平,以及不良反应发生率。结果:观察组治疗总有效率为97.33%,高于对照组的86.67%,差异有统计学意义(P<0.05);观察组便血/呕血消失时间短于对照组,差异有统计学意义(P<0.05);两组腹痛、头晕、恶心等症状消失时间比较,差异均无统计学意义(P>0.05);治疗后,观察组取血清IL-8水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:瑞巴派特、生长抑素、奥美拉唑三联疗法可提高胃溃疡出血的治疗总有效率,缩短呕血/便血消失时间,降低炎性因子水平,效果优于单用生长抑素和奥美拉唑治疗。
Objective:To explore effects of Rebamipide combined with Omeprazole and Somatostatin in treatment of patients with gastric ulcer bleeding.Methods:The clinical data of 150 patients with gastric ulcer bleeding admitted to our hospital from April 2019 to April 2020 were retrospectively analyzed.According to different treatment methods,these patients were divided into control group and observation group,75 cases in each.The control group was treated with oral Omeprazole enteric-coated tablets and intravenous infusion of Somatostatin,while the observation group was additionally treated with Rebamipide tablets.The clinical effects,the disappearance time of symptoms such as abdominal pain,dizziness,nausea,blood in the stool/hemoptysis,the serum interleukin-8(IL-8)level before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.33%,which was higher than 86.67%of the control group,and the difference was statistically significant(P<0.05).The disappearance time of blood in the stool/hematemesis in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).However,there were no significant differences in the disappearance time of abdominal pain,dizziness,nausea and other symptoms between the two groups(P>0.05).After the treatment,the serum level of IL-8 in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:The triple therapy of Rebamipide,Somatostatin and Omeprazole can improve the total effective rate of gastric ulcer bleeding,shorten the disappearance time of hematemesis/blood in the stool,and reduce the levels of inflammatory factors.Moreover,it is superior to Somatostatin and Omeprazole treatment.
作者
王娜
WANG Na(The Fourth Department of Internal Medicine of the Eighth People’s Hospital of Luoyang City,Luoyang 471000 Henan,China)
出处
《中国民康医学》
2022年第6期26-28,共3页
Medical Journal of Chinese People’s Health
