摘要
目的:探讨合并2型糖尿病对结核性胸膜炎患者外周血及胸腔积液结核感染T细胞斑点试验(T-SPOT.TB)检测结果的影响。方法:收集2016—2021年西安市胸科医院收治的诊断为结核性胸膜炎的444例患者,依据是否合并2型糖尿病,分为结核性胸膜炎合并2型糖尿病组(合并糖尿病组;116例)和未合并糖尿病的结核性胸膜炎组(非糖尿病组;328例)。分别采集两组患者抗结核药物治疗前胸腔积液和外周血标本,进行T-SPOT.TB检测,分析两组患者T-SPOT.TB检测结果的差异。结果:合并糖尿病组和非糖尿病组患者外周血T-SPOT.TB检测阳性率分别为46.55%(54/116)和56.10%(184/328),差异无统计学意义(χ^(2)=3.140,P=0.076);胸腔积液T-SPOT.TB检测阳性率分别为65.52%(76/116)和88.41%(290/328),合并糖尿病组明显低于非糖尿病组,差异有统计学意义(χ^(2)=31.025,P<0.001)。合并糖尿病组和非糖尿病组患者胸腔积液T-SPOT.TB检测阳性率均高于外周血,差异均有统计学意义(χ^(2)=4.845,P=0.028;χ^(2)=12.848,P<0.001)。结论:当结核性胸膜炎患者合并2型糖尿病时,胸腔积液T-SPOT.TB检测阳性率降低,但仍高于外周血T-SPOT.TB检测结果;建议考虑优先行胸腔积液T-SPOT.TB检测,以提高阳性检出率。
Objective:To investigate the effect of type 2 diabetes mellitus on the results of T-cell spot test for tuberculosis infection(T-SPOT.TB)of the peripheral blood and pleural effusion in patients with tuberculous pleurisy.Methods:According to whether complicated with type 2 diabetes mellitus,444 tuberculous pleurisy patients from Xi’an Chest Hospital between 2016 and 2021 were divided into tuberculous pleurisy complicated with type 2 diabetes mellitus group(n=116)and tuberculous pleurisy without type 2 diabetes mellitus group(n=328).The pleural effusion and peripheral blood specimens of the two groups before medical treatment were collected for T-SPOT.TB,and the results were compared.Results:The positive rates of peripheral blood T-SPOT.TB were 46.55%(54/116)in the tuberculous pleurisy complicated with type 2 diabetes mellitus group and 56.10%(184/328)in the tuberculous pleurisy without type 2 diabetes mellitus group,respectively,and there was no significant difference between the two groups(χ^(2)=3.140,P=0.076).The positive rate of pleural effusion T-SPOT.TB in the tuberculous pleurisy complicated with type 2 diabetes mellitus group was significantly lower than that in the tuberculous pleurisy without type 2 diabetes mellitus group(65.52%(76/116)vs.88.41%(290/328),χ^(2)=31.025,P<0.001).By T-SPOT.TB,the positive rates in pleural effusion were significantly higher than those in peripheral blood in both two groups(χ^(2)=4.845,P=0.028;χ^(2)=12.848,P<0.001).Conclusion:When tuberculous pleurisy patients complicated with type 2 diabetes mellitus,the positive rate of T-SPOT.TB in pleural effusion was decreased,but it was still higher than that in peripheral blood.Pleural effusion T-SPOT.TB detection was recommended to improve the positive detection rate.
作者
刘媛
剧猛
左蕾
张耀辉
黄毅
LIU Yuan;JU Meng;ZUO Lei;ZHANG Yao-hui;HUANG Yi(Department of Clinical Laboratory,Xi’an Chest Hospital,Xi’an 710100,China;Department of Ultrasonography,Xi’an Chest Hospital,Xi’an 710100,China;Department of Statistics,Xi’an Chest Hospital,Xi’an 710100,China)
出处
《中国防痨杂志》
CAS
CSCD
2022年第5期489-493,共5页
Chinese Journal of Antituberculosis
基金
陕西省重点研发项目(2021SF-015)
西安市科技计划项目(J201902024)。
关键词
糖尿病
2型
结核
胸膜
共病现象
酶联免疫吸附测定
对比研究
Diabetes mellitus,type 2
Tuberculosis,pleural
Comorbidity
Enzyme-linked immunosorbent assay
Comparative study
