摘要
目的探讨凝血四项联合血清胆碱酯酶(CHE)水平检测对病毒性肝炎患者阳性检出率的影响。方法以50例病毒性肝炎患者为对象(急性肝炎6例,慢性肝炎25例、肝炎后肝硬化13例、重型肝炎6例),以同期50例健康人为对照组。检测两组凝血指标及CHE水平,分析其检出病毒性肝炎的阳性率。结果观察组纤维蛋白原Fbg、CHE水平高于对照组,活化部分凝血活酶时间(aPTT)、凝血酶原时间(PT)、凝血酶时间(TT)水平高于对照组(P <0.05)。急性肝炎、慢性肝炎、肝炎后肝硬化、重型肝炎患者aPTT、PT、TT、Fbg、CHE水平比较差异显著(P <0.05);Fbg、CHE水平在急性肝炎组、慢性肝炎组、肝炎后肝硬化组、重型肝炎组依次降低(P <0.05),而aPTT、PT、TT水平在急性肝炎组、慢性肝炎组、肝炎后肝硬化组、重型肝炎组依次升高(P <0.05)。凝血四项与血清CHE联合检测诊断急性肝炎、慢性肝炎、肝炎后肝硬化及重型肝炎的准确度均分别为83.33%、92.00%、92.31%、100.00%,高于二者单独检测(P <0.05)。结论病毒性肝炎患者凝血功能受到抑制,CHE水平降低,凝血指标、CHE与病毒性肝炎患者的病情关系密切,联合二者有助于提高病毒性肝炎的检出率。
Objective To investigate the effect of four coagulation items combined with serum cholinesterase( CHE) level on the positive detection rate of viral hepatitis. Methods 50 patients with viral hepatitis were selected as the subjects( 6 cases of acute hepatitis,25 chronic hepatitis,13 cases of cirrhosis after hepatitis and 6 cases of severe hepatitis),and 50 healthy patients were taken as control group. The coagulation index and Che level of the two groups were detected,and the positive rate of viral hepatitis was analyzed. Results The Fbg and Che levels of the observation group were higher than that of the control group,and the activated part of the thrombin time( aPTT),prothrombin time( PT),and thrombin time( TT)were higher than that of the control group( P < 0. 05). The levels of aPTT,Pt,TT,Fbg and Che were significantly different in patients with acute hepatitis,chronic hepatitis,post hepatitis cirrhosis and severe hepatitis( P < 0. 05);The levels of Fbg and Che were decreased in the acute hepatitis group,chronic hepatitis group,post hepatitis cirrhosis group and severe hepatitis group( P < 0. 05),while the levels of aPTT,Pt and TT were increased in the acute hepatitis group,chronic hepatitis group,post hepatitis cirrhosis group and severe hepatitis group( P < 0. 05). The accuracy of the combined detection of coagulation and serum ChE in the diagnosis of acute hepatitis,chronic hepatitis,post hepatitis cirrhosis and severe hepatitis was 83. 33%,92. 00%,92. 31% and 100. 00%,respectively,which was higher than that of the two alone( P < 0. 05).Conclusion The coagulation function of patients with viral hepatitis is inhibited,Che level is reduced,coagulation index and Che are closely related to the condition of patients with viral hepatitis,and the combination of them can improve the detection rate of viral hepatitis.
作者
苏莹
杨倩
李艳
SU Ying;YANG Qian;LI Yan(Department of Laboratory Medicine,Nanzheng District People’s Hospital,Hanzhong City,Shaanxi Province,Hanzhong,723100,China;Department of Laboratory Medicine,Shaanxi Provincial People’s Hospital,Xi’an,710000,China)
出处
《血栓与止血学》
CAS
2022年第2期195-197,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
凝血四项
胆碱酯酶
病毒性肝炎
coagulation four items
Cholinesterase
Viral hepatitis
