摘要
目的:对银杏叶提取物的研究趋势进行归纳和分析,为银杏叶的未来研究提供参考。方法:检索“银杏叶”提取物已发表文献,委托国家图书馆进行已发表文献的专业检索,对文献中银杏叶提取物的药学研究趋势进行梳理归纳并分析。结果与结论:文献整理发现,银杏叶提取物在提取工艺方面,以乙醇提取后过大孔树脂柱处理的工艺应用最为广泛,提取效率也最高效。化学成分方面,主要有效成分为银杏黄酮和银杏内酯,主要毒性成分为银杏酸。药理作用方面,银杏叶提取物的主要功效是抑制血小板凝聚、抗氧化、抗炎、改善记忆、降血脂和心脑血管保护等,使用银杏叶提取物优于单独使用银杏黄铜或银杏内酯。安全性研究方面,银杏叶提取物总体使用安全,文献报道的热点集中在银杏酸的致敏性。银杏叶提取物的质量控制关键是其活性成分银杏黄酮和银杏内酯,安全性控制关键在于银杏酸的限量。
Objective:To summarize and analyze the research trend of ginkgo biloba leaves extract,and provide references for the future research of ginkgo biloba leaves.Methods:The published literatures of ginkgo biloba extract were retrieved,and the National Library of China was commissioned to conduct professional retrieval of published literatures.The pharmaceutical research trends of ginkgo biloba extract in the literatures were summarized and analyzed.Results and Conclusion:After literature review,it was found that ethanol extraction with macroporous resin column treatment was most widely used,and the extraction efficiency was the highest.In terms of chemical composition,the main active components are ginkgo flavone and ginkgolide,and the main toxic component is ginkgolic acid.In terms of pharmacological effects,the main effects of ginkgo biloba leaf extract are inhibition of platelet aggregation,anti-oxidation,anti-inflammation,improvement of memory,lowering blood lipids and cardiovascular and cerebrovascular protection,etc.Using ginkgo biloba leaf extract is superior to using ginkgo brass or ginkgolides alone.In terms of safety studies,ginkgo biloba leaf extract is generally safe in use,and literatures focus are on the sensitization of ginkgo acid.The key to the quality control of ginkgo biloba leaf extract is its active components,ginkgo flavone and ginkgolide;and the key to the safety control lies in the limit of ginkgo acid.
作者
肖斯婷
曹春然
刘红艳
高晓新
孙圆媛
赵晋燕
李雪梅
郭玉东
朱春玥
陈薪宇
王佳帅
李爽
彭玉
王瑶
王旭
胡宇驰
郭洪祝
杨文良
蔡铁全
陈广耀
Xiao Siting;Cao Chunran;Liu Hongyan;Gao Xiaoxin;Sun Yuanyuan;Zhao Jinyan;Li Xuemei;Guo Yudong;Zhu Chunyue;Chen Xinyu;Wang Jiashuai;Li Shuang;Peng Yu;Wang Yao;Wang Xu;Hu Yuchi;Guo Hongzhu;Yang Wenliang;Cai Tiequan;Chen Guangyao(Beijing Institute for Drug Control,Beijing 102206,China;Food Evaluation Center,State Administration for Market Regulation,Beijing 100070,China)
出处
《中国药事》
CAS
2022年第4期429-443,共15页
Chinese Pharmaceutical Affairs
关键词
银杏叶提取物
活性
毒性
安全性
提取工艺
化学成分
药理作用
质量控制
ginkgo biloba leaf extract
activity
toxicity
security
extraction process
chemical composition
pharmacological action
quality control
