摘要
目的 探讨接种2剂次肠道病毒71型(enterovirus71,EV71)灭活疫苗对适龄儿童重症手足口病(hand, foot and mouth disease, HFMD)的保护效果(vaccine efficacy, VE)。方法 选取广西壮族自治区妇幼保健院重症医学科2016年9月至2020年9月收治并上报中国疾病预防控制信息系统的109例6个月~5岁EV71型重症HFMD为病例组。按照1∶1配对,收集109例6个月~5岁健康儿童为对照组进行回顾性病例对照研究,计算EV71灭活疫苗的VE。结果 病例组2剂次EV71灭活疫苗的接种率明显低于对照组(9.17%比54.13%,χ^(2)=50.911,P<0.05);OR=0.086(95%CI:0.040~0.182),EV71灭活疫苗的VE为91.44%(95%CI:81.8%~96%)。结论 EV71灭活疫苗对EV71引起的重症HFMD发病有很好的保护作用,应该继续推广接种EV71灭活疫苗。
Objective To investigate the vaccine efficacy(VE) of two doses of inactivated enterovirus 71(EV71) vaccine on severe hand, foot, and mouth disease(HFMD) in eligible children. Methods A retrospective case-control study was conducted in this project.A total of 109 patients with EV71 severe HFMD aged between 6 months to 5 years old who were admitted to the Pediatric Intensive Care Unit(PICU) of Guangxi Maternity and Child Health Hospital from September 2016 to September 2020,andreported to the Chinese Disease Prevention and Control Information System were selected as the case group.According to 1:1 matching, 109 healthy children aged between 6 months to 5 years old were selectedas the control group.The vaccine efficacy of EV71 inactivated vaccine was calculated. Results The vaccination rate of the two doses of inactivated EV71 vaccine in the case group was significantly lower than that in the control group(9.17 % to 54.13%,(χ^(2)=50.911,P<0.05;OR=0.086(95% CI:0.040-0.182).The vaccine efficacy of two doses of inactivated EV71 vaccine was 91.44%(95% CI:81.8%-96%). Conclusion The inactivated EV71 vaccine has a good protective effect on hand, foot, and mouth disease caused by EV71.The vaccination of EV71 inactivated vaccine should be continuously promoted.
作者
韦跃
谢友军
陈月华
林明
WEI Yue;XIE You-jun;CHEN Yue-hua;LIN Ming(Guangxi Maternity and Child Health Hospitalthe,Nanning,Guangxi 530003,China)
出处
《公共卫生与预防医学》
2022年第3期37-40,共4页
Journal of Public Health and Preventive Medicine
基金
广西自然科学基金项目(2013GXNSFAA019256)。
