摘要
目的:采用Meta分析的方法对鼻渊通窍颗粒治疗小儿慢性鼻窦炎的有效性和安全性进行评价。方法:计算机检索CNKI、WanFang Data、VIP、SinoMed、PubMed、Cochrane Library、Embase数据库,搜集关于鼻渊通窍颗粒治疗小儿慢性鼻窦炎的随机对照试验(RCT),检索时限均为从建库至2021年12月12日。由两位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3、Stata 12.0软件进行数据分析。结果:共纳入13项研究,累计1749例患者。Meta分析结果显示,对比仅用西医常规疗法,鼻渊通窍颗粒联用西医常规疗法治疗小儿慢性鼻窦炎可提高临床总有效率[RR=1.18,95%CI(1.13,1.23),P<0.001],降低患者病情严重程度视觉模拟评分[MD=-7.51,95%CI(-8.05,-6.96),P<0.001]、降低血清白细胞介素-2(IL-2)水平[MD=-5.03,95%CI(-6.14,-3.92),P<0.001]、改善鼻窦CT情况[MD=-5.25,95%CI(-5.92,-4.59),P<0.001],两种治疗方案降低Lund-Kennedy鼻内镜评分[MD=-2.36,95%CI(-4.93,0.21),P=0.07]和血清白细胞介素-6(IL-6)水平[MD=-0.84,95%CI(-13.13,11.44),P=0.89]的差异均无统计学意义。结论:当前纳入研究证据表明,在西医常规疗法的基础上联用鼻渊通窍颗粒治疗小儿慢性鼻窦炎的疗效优于仅用西医常规疗法,且没有严重的药品不良反应发生,但仍需要更多大样本、多中心的随机对照试验来进一步验证本研究结论。
Objective:To systematically evaluate the clinical efficacy and safety of Biyuan Tongqiao particle(BYTQ)in treatment of children chronic sinusitis(CRS).Methods:Databases including CNKI,WanFang Data,VIP,SinoMed,PubMed,Cochrane Library and Embase were searched to collect randomized controlled trials(RCTs)regarding BYTQ in the treatment of children CRS from the inception to December 12 th,2021.Two researchers independently screened literature,extracted data,and assessed the risk of bias of included studies,and then Meta-analyzed was performed using RevMan 5.3 and Stata 12.0 software.Results:A total of 13 RCTs with 1749 patients were included.The results of meta-analysis showed that,BYTQ with routine western medicine(WM)could achieve a better effect than WM in respect of total effective rate(RR=1.18,95%CI 1.13 to 1.23,P<0.001).And BYTQ could reduce visual analogue scale/score(MD=-7.51,95%CI-8.05 to-6.96,P<0.001),serum IL-2 level(MD=-5.03,95%CI-6.14 to-3.92,P<0.001).In addition,BYTQ could improve sinus CT(MD=-5.25,95%CI-5.92 to-4.59,P<0.001).There were no significant difference in Lund-Kennedy(MD=-2.36,95%CI-4.93 to 0.21,P=0.07)and serum IL-6 level(MD=-0.84,95%CI-13.13 to 11.44,P=0.89)between two groups.Conclusion:BYTQ with WM is more effective in treating of children CRS than WM,and no serious adverse reactions occurred.However,more large,multi-center RCTs are needed to further verify the conclusions of this study.
作者
王艺璇
巫志姗
王郝嘉
张景媛
刘鑫馗
吴嘉瑞
Wang Yixuan;Wu Zhishan;Wang Haojia;Zhang Jingyuan;Liu Xinkui;Wu Jiarui(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100102,China)
出处
《药物流行病学杂志》
CAS
2022年第4期219-227,共9页
Chinese Journal of Pharmacoepidemiology
基金
国家自然科学基金项目(编号:82074284)。
关键词
鼻渊通窍颗粒
小儿慢性鼻窦炎
META分析
随机对照试验
Biyuan Tongqiao particle
Children chronic sinusitis
Meta-analysis
Randomized controlled trial
