摘要
目的比较不同方法治疗女性型脱发(FPHL)的有效率及安全性,为临床治疗提供依据。方法选取2021年3~6月首都医科大学附属北京友谊医院皮肤科门诊招募的18~45岁,Sinclair分级为Ⅱ、Ⅲ级月经规律的120例FPHL患者进行前瞻性研究。使用计算机生成随机数字表,患者抽签随机分为3组:米诺地尔组:每日一次外涂5%米诺地尔溶液1 mL;微针联合米诺地尔组:每日外涂米诺地尔溶液+每2周一次微针导入米诺地尔溶液,12次;微针联合域发生发液组:外涂域发生发液每日2次,每2周一次微针导入生发液治疗,12次;比较24周时不同治疗组内和组间毛发生长情况(毛发镜下毛发密度、毛干直径),医师评价(Sinclair脱发分级变化、7级评分法)、患者评价(毛发脱落评分、生活质量调查问卷、主观满意度)及不良反应发生情况。结果治疗前,3组患者基本信息及毛发密度和毛干直径等差异无统计学意义(P>0.05)。24周时,3组患者毛发镜下平均毛发密度和毛干直径均较治疗前增加,差异均有统计学意义(P<0.05);3组间比较,微针联合米诺地尔组毛发密度增加最明显(P<0.05),米诺地尔组和微针联合域发生发液组间差异无统计学意义(P>0.05)。3组间毛干直径比较,差异无统计学意义(P>0.05)。医师评价(Sinclair分级评定、7级评分法)、患者评价(毛发脱落评分、生活质量调查问卷、主观满意度)显示3组脱发程度均较治疗前有显著好转,差异均有统计学意义(P<0.05)。微针联合域发生发液组不良反应发生率为10.5%(4/38),显著低于米诺地尔组[71.1%(27/38)]和微针联合米诺地尔组[60.0%(24/40)],差异有统计学意义(P<0.05)。结论3种治疗方式中,微针联合米诺地尔溶液是治疗FPHL最有效的方式,单纯外涂米诺地尔溶液与微针联合域发生发液疗效无差异,微针联合域发生发液治疗组不良反应最小。
Objective This study aims to compare the efficacy and safety of different treatment methods for female pattern hair loss(FPHL)patients,so as to provide evidence for clinical treatment.Methods A total of 120 FPHL(Sinclair's stage II-Ⅲ)with regular menses aged between 18 and 45 years were recruited in this prospective study in the Department of Dermatology,Beijing Friendship Hospital,Capital Medical University.According to the random number table created by the computer software,each participant was assigned a number and randomly divided into three groups:the minoxidil group:topical 5%minoxidil solution with 1 mL once daily;microneedle combined with minoxidil group:topical minoxidil solution and microneedle every 2 weeks(12 times);microneedle combined with Yu fa solution group:microneedle every 2 weeks(12 times)and topical Yu fa solution twice a day.At week 24,hair indexes within and between different groups were compared.The evaluation included hair growth(hair density and hair shaft diameter under dermatoscope),physician evaluation(Sinclair's stage change and 7-point global-assessment scale),patient evaluation(hair shedding score,the women's androgenetic alopecia quality of life questionnaire and patients'satisfaction)and the adverse effects.Results Before treatment,there were no significant differences in basic information,hair density and hair shaft diameter among the three groups.At week 24,the average hair density and hair shaft diameter under the dermatoscope in any each group were increased compared to the baseline,and the differences were statistically significant(P<0.05).Among the three groups,the hair density increased most obviously in the microneedle combined with minoxidil group(P<0.05).And there was no significant difference between the minoxidil group and the microneedle combined with Yu fa group(P>0.05).There was no statistical difference in hair shaft diameter among 3 groups.Physician evaluation(Sinclair's stage change and 7-point global-assessment scale),patient evaluation(hair shedding score,the women's androgenetic alopecia quality of life questionnaire and patients'satisfaction)showed hair loss in all three groups improved significantly compared to the baseline.The incidence of adverse reactions in the microneedle combined with Yu fa solution group was 10.5%(4/38),which was significantly lower than that in the minoxidil group[71.1%(27/38)]and the microneedle combined with minoxidil group[60.0%](24/40)],the difference was statistically significant(P<0.05).Conclusion Among the three treatment methods,microneedle combined with minoxidil solution is the most effective way to treat FPHL.There is no difference in the efficacy between minoxidil solution alone and microneedle combined with Yu fa solution,and microneedle combined with Yu fa group has the least adverse reactions.
作者
梁雪蕾
刘沂
吴海铉
赵暕
常远
王乐一
禚风麟
LIANG Xue-lei;LIU Yi;WU Hai-xuan(Department of Dermatology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)
出处
《临床和实验医学杂志》
2022年第7期739-744,共6页
Journal of Clinical and Experimental Medicine
基金
北京市自然科学基金(编号:722240)。
关键词
女性型脱发
米诺地尔溶液
微针
域发生发液
疗效
安全性
Female pattern hair loss
Minoxidil solution
Microneedle
Yu fa solution
Efficacy
Safety
