摘要
目的探讨同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)检测对冠状动脉粥样硬化患者的意义。方法选择医院2019年1月—2021年7月接收的健康体检者64名为对照组,另选择同期接收冠心病患者64例为研究组,均检测Hcy和hs-CRP水平,比较两组Hcy、hs-CRP水平以及异常检出率的差异。并根据研究组冠心病患者病情,将其分为稳定型心绞痛、不稳定型心绞痛、急性心肌梗死3组,比较3组Hcy、hs-CRP水平差异。结果研究组Hcy、hs-CRP水平分别为(17.87±2.14)μmol/L、(12.17±1.58)mg/L,高于对照组;研究组异常检出率分别为60.94%、65.63%,高于对照组,差异有统计学意义(t=34.430、50.933,χ^(2)=42.900、40.506,P<0.05)。急性心肌梗死组Hcy、hs-CRP水平分别为(20.14±1.77)μmol/L、(15.60±2.21)mg/L,高于不稳定型心绞痛组与稳定型心绞痛组水平,差异有统计学意义(t=4.255、7.970、8.845、23.980,P<0.05)。结论冠状动脉粥样硬化患者Hcy、hs-CRP水平及异常检出率均较高,且病情越严重Hcy、hs-CRP水平越高。
Objective To investigate the significance of homocysteine(Hcy)and high-sensitivity C-reactive protein(hs-CRP)detection in patients with coronary atherosclerosis.Methods A total of 64 healthy people who received physical examinations in the hospital from January 2019 to July 2021 were selected as the control group,and 64 patients with coronary heart disease received during the same period were selected as the study group,and the levels of homocysteine and high-sensitivity C-reactive protein were detected,and compared the differences in the levels of Hcy,hs-CRP and abnormal detection rate between the two groups.According to the condition of coronary heart disease patients in the study group,they were divided into three groups:stable angina pectoris,unstable angina pectoris,and acute myocardial infarction,and the differences in the levels of Hcy and hs-CRP among the three groups were compared.Results The levels of Hcy and hs-CRP in the study group were(17.87±2.14)μmol/L and(12.17±1.58)mg/L,respectively,which were higher than those in the control group;the abnormal detection rates in the study group were 60.94%and 65.63%,respectively,which were higher than those in the control group,the difference was statistically significant(t=34.430,50.933,χ^(2)=42.900,40.506,P<0.05).The levels of Hcy and hs-CRP in the acute myocardial infarction group were(20.14±1.77)μmol/L and(15.60±2.21)mg/L,respectively,which were higher than those in the unstable angina group and stable angina group,and the difference was statistically significant(t=4.255,7.970,8.845,23.980,P<0.05).Conclusion The levels of Hcy and hs-CRP and the abnormal detection rate in patients with coronary atherosclerosis are higher,and the more severe the disease,the higher the levels of Hcy and hs-CRP.
作者
缪雪梅
MIAO Xuemei(Department of Laboratory Medicine,Pukou District Hospital of Traditional Chinese Medicine,Nanjing,Jiangsu Province,211800 China)
出处
《系统医学》
2022年第4期91-94,共4页
Systems Medicine
关键词
同型半胱氨酸
超敏C反应蛋白
冠状动脉粥样硬化
心绞痛
心肌梗死
Homocysteine
High-sensitivity C-reactive protein
Coronary atherosclerosis
Angina pectoris
Myocardial infarction
