摘要
目的:探究改良阿特金斯饮食(MAD)对超重或肥胖多囊卵巢综合征(PCOS)患者糖脂代谢、体成分、性激素水平及月经周期的影响。方法:选择2020年6月1日-2021年3月31日在徐州市第一人民医院、徐州市第六人民医院就诊的超重/肥胖PCOS患者80例,随机分为两组各40例。均行3个月干预,对照组给予常规治疗与生活方式建议,MAD组采用MAD干预。对所有患者进行基线评估,比较干预前与干预1、2、3个月后两组糖代谢、脂代谢、性激素水平,比较干预前与干预3个月后两组体成分指标及月经状况、不良反应发生情况。结果:干预1、2、3个月后,两组血糖、总胆固醇、甘油三酯、低密度脂蛋白呈下降趋势且MAD组低于对照组,高密度脂蛋白水平呈上升趋势且MAD组高于对照组(均P<0.05)。干预后3个月,两组体重、体质指数、体脂率、腰围、肌肉量及内脏脂肪区域水平均下降,MAD组体重、体质指数、体脂率、腰围及内脏脂肪区域水平低于对照组,肌肉量水平高于对照组;干预后1、2、3个月,两组性激素水平均呈下降趋势且MAD组低于对照组;MAD组自然成功受孕率(17.5%)高于对照组(2.5%),不良反应发生率(5.0%)低于对照组(20.0%)(均P<0.05)。结论:对超重/肥胖的PCOS患者采取MAD干预疗效较好,能够显著改善患者糖脂代谢及体成分指标,调节性激素水平,促进月经周期恢复、提升自然受孕率,降低不良反应发生。
Objective:To explore the effects of the modified Atkins diet(MAD)for intervention of overweight or obese pregnant women with polycystic ovarian syndrome(PCOS)on their glucolipid metabolism,body composition,sex hormone levels,and menstrual cycle.Methods:80 overweight or obese pregnant women with PCOS who met the inclusion and exclusion criteria at the first or the sixth People’s hospital of Xuzhou were recruited as the study subjects from June 1,2020 to March 31,2021.These women were divided into experimental group and control group(40 cases in each group)according to the principle of random allocation.The women in the control group were given conventional treatment and lifestyle recommendations for 3 months,and the women in the experimental group were treated with modified Atkins diet(MAD)intervention for 3 months.The baseline assessment was conducted on all these women.The levels of glucose metabolism indexes,lipid metabolism indexes,and sex hormone of the women in the two groups before intervention and 1,2,3 months after intervention were compared.The body composition indexes,the menstrual status,and the occurrence of adverse reactions of the women in the two groups before intervention and 3 months after intervention were compared.Results:After 1,2,3 months of intervention,the levels of blood glucose,total cholesterol,triglyceride,and low density lipoprotein of the women in the two groups had a decreasing trend,and which of the women in the experimental group were significantly lower than those of the women in the control group.While the level of high density lipoprotein of the women in the two groups had increasing trend,and which of the women in the experimental group was significantly higher than that of the women in the control group(all P<0.05).Three months after intervention,the body composition indexes,such as body weight,body mass index,body fat percentage,waist circumference,muscle mass,and visceral fat region of the women in both groups had decreased significantly.The values of weight,body mass index,body fat percentage,waist circumference,and visceral fat region of the women in the experimental group were significantly lower than those of the women in the control group,and the value of muscle amount of the women in the experimental group was significantly higher than that of the women in the control group(all P<0.05).In 1,2,and 3 months after intervention,the levels of sex hormones of the women in both groups showed a decreasing trend,and which of the women in the experimental group were significantly lower than those of the women in the control group(P<0.05).The rate of successful nature pregnancy(17.5%)of the women in experimental group was significantly higher than that(2.5%)of the women in control group,and the incidence of adverse reactions(5.0%)of the women in experimental group was significantly lower than that(20.0%)of the women in the control group(all P<0.05).Conclusion:MAD intervention of the overweight or obese women with PCOS has good effect,which can significantly improve their glucose and lipid metabolism level and body composition indicators,regulate their sex hormone levels,promote the recovery of their menstrual cycle,increase their probability of natural pregnancy,and reduce the probability of adverse reactions.
作者
郑小莉
刘永利
张秀智
ZHENG Xiaoli;LIU Yongli;ZHANG Xiuzhi(Xuzhou Municipal Hospital(The First People's Hospital of Xuzhou),Xuzhou Medical University,Jiangsu Province,221000)
出处
《中国计划生育学杂志》
2022年第3期582-586,591,共6页
Chinese Journal of Family Planning
基金
徐州医科大学附属医院发展基金资助项目(面上项目)(XYFM2020045)。
关键词
多囊卵巢综合征
超重
肥胖
改良阿特金斯饮食
糖脂代谢
体成分
性激素
月经周期
自然受孕
Polycystic ovary syndrome
Overweight
obesity
Modified Atkins diet
Glucose and lipid metabolism
Body composition
Sex hormones
Menstrual cycle
Natural pregnancy
