摘要
膜性肾病(membranous nephropathy,MN)是靶抗原与抗体形成免疫复合物后沉积于肾小球引起的一种自身免疫性疾病。该疾病的诊断主要依靠经皮肾脏活组织检查术和血清学PLA2R1检测,但为了进一步提高PLA2R1阴性MN患者及继发性膜性肾病的诊断率,同时对拒绝肾活检患者进行更准确的诊断,血清学检测尤为重要。靶抗原的逐步发现恰好为我们诊断这部分MN提供了有力的血清学依据。此外,基因学的发展也为该疾病的诊断及治疗提供了新方向。因此,非常有必要明确MN的发病机制,为进一步指导该疾病的诊断治疗及预后预测提供有价值的参考。
Membranous nephropathy(MN)is a kind of autoimmune disease caused by forming immune complex of antigen and antibody in glomerulus.A definite diagnosis is dependent upon renal biopsy and serological PLA2R1 test.And serological test is vital for further boosting the diagnostic rate of PLA2R1-negative membranous nephropathy and secondary membranous nephropathy and reaching a more accurate diagnosis in patients declining renal biopsy.Recent discovery of target antigen provides a robust serological basis for diagnosing this subset of membranous nephropathy.Also genetic advances have provided new directions for its diagnosis and treatment.Therefore it is imperative to clarify the pathogenesis of membranous nephropathy to provide valuable references for further improvements of its diagnosis,treatment and prognosis.
作者
贺志花
王利华
He Zhi-hua;Wang Li-hua(Department of Nephrology,Second Clinical College,Shanxi Medical University,Taiyuan 030000,Chma)
出处
《临床肾脏病杂志》
2022年第5期423-428,共6页
Journal Of Clinical Nephrology
关键词
肾小球肾炎
膜性
抗原
受体
磷脂酶A2
基因
Glomerulonephritis,membranous
Antigens
Receptors,Phospholipase A2
Genes
