摘要
目的 观察丹红注射液联合西药治疗冠心病不稳定型心绞痛的临床疗效及安全性。方法 选取2018年10月—2020年5月期间中国人民解放军火箭军特色医学中心心内科收治的112例冠心病不稳定型心绞痛患者作为研究对象,按照随机数字表法分为对照组和治疗组,每组各56例。对照组给予常规西药治疗,治疗组在西药治疗基础上联合丹红注射液治疗。治疗4周后,观察比较两组患者心绞痛发作改善情况、硝酸甘油减停率、治疗前后血清炎症因子[五聚素-3(Pentraxin-3,PTX-3)、脂蛋白相关磷脂酶A2(Lipoprotein-associated phospholipaseA2,Lp-PLA2)、血管细胞黏附分子-1(Vascular cell adhesion molecule-1,VCAM-1)]水平、生活质量(Seattle angina questionnaire, SAQ)评分及不良反应情况。结果 两组患者治疗后心绞痛发作频率、持续时间均较治疗前改善,差异有统计学意义(P<0.05);且治疗组优于对照组,差异有统计学意义(P<0.05)。治疗后治疗组硝酸甘油减停率94.64%(53/56)较对照组80.36%(45/56)明显升高,差异有统计学意义(P<0.05)。两组患者治疗后血清PTX-3、Lp-PLA2、VCAM-1水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组较对照组明显降低,差异有统计学意义(P<0.05)。两组患者治疗后SAQ评分均较治疗前升高,差异有统计学意义(P<0.05);且治疗组较对照组明显升高,差异有统计学意义(P<0.05)。治疗期间,两组患者均未发生不良反应。结论 丹红注射液联合西药治疗冠心病不稳定型心绞痛安全、有效,有较高临床价值。
Objective To explore the clinical efficacy and safety of DanhongInjection in assisting with basic western medicine treatment for unstable angina pectoris of coronary heart disease.Methods A total of 112 patients with unstable angina pectoris of coronary heart disease treated in the department of cardiology, PLA Rocket Force Characteristic Medical Center from October 2018 to May 2020 were randomly divided into a control group(n=56)and a treatment group(n=56)according to the random number table.All patients were treated with conventional western medicine, while those in the treatment group received additionalDanhongInjection.After four weeks of treatment, the improvement of angina pectoris attack, the reduction rate of nitroglycerin, the levels of serum inflammatory factors[pentamer-3(PTX-3),lipoprotein-related phospholipase A2(Lp-PLA2),and vascular cell adhesion molecule-1(VCAM-1)]before and after treatment, the Seattle Angina Questionnaire(SAQ)scores, and adverse eventsof the two groups were compared.Results The frequency and duration of angina pectoris in both groups were improved after treatment(P<0.05),and the treatment group was superior to the control group(P<0.05).The reduction rate of nitroglycerin in the treatment group was 94.64%(53/56),higher than 80.36%(45/56)in the control group(P<0.05).After treatment, the serum levels of PTX-3,Lp-PLA2,and VCAM-1 in the two groups were lower than those before treatment(P<0.05),and the treatment group was lower than the control group(P<0.05).After treatment, the SAQ scores of both groups were higher than those before treatment(P<0.05),and the treatment group was higher than the control group(P<0.05).No adverse events occurred in both groups during treatment.Conclusion DanhongInjection combined with western medicine is safe and effective in the treatment of unstable angina pectoris of coronary heart disease, possessing high clinical value.
作者
姚媛媛
靳志涛
YAO Yuan-yuan;JIN Zhi-tao(Department of Cardiology,PLA Rocket Force Characteristic Medical Center,Beijing 100080)
出处
《世界中西医结合杂志》
2022年第4期769-773,共5页
World Journal of Integrated Traditional and Western Medicine
基金
北京中医药科技发展资金项目(QN2016-06)。
