摘要
凝血因子(F)Ⅴ是调控并参与凝血初始反应的必需因子,对凝血酶的生成有极其重要的影响。最新研究发现FⅤ还具有抗凝特性。FⅤ基因(F5)的不同突变导致了出血或者血栓的形成。F5功能缺陷型突变常导致出血,如遗传性凝血因子Ⅴ缺陷症(FⅤD)患者多表现为不同程度的出血;但F5功能获得性突变则易形成血栓,如FⅤ_(Leiden)突变是高加索人群静脉血栓形成最常见的遗传危险因素。文章对FⅤ与出血和血栓相关性的研究进展进行综述。
Coagulation factor(F)Ⅴis an essential factor to participate in the initial phase of coagulation,which plays a role in the production of thrombin.It is recently suggested that FⅤalso harbors anticoagulant properties.Different mutations in the FⅤgene(F5)cause bleeding or thrombosis.F5 dysfunction mutations often lead to bleeding.For example,patients with hereditary coagulation factorⅤdeficiency(FⅤD)often show different degrees of bleeding.However,F5 gain-of-function mutations are prone to thrombosis.FⅤ_(Leiden) mutation is the most common genetic risk factor for venous thrombosis in Caucasians.This review mainly focuses on the research progress of the association of FⅤwith hemorrhage and thrombosis.
作者
李可可
肖扬
LI Keke;XIAO Yang(Dongguan Tungwah Hospital,Dongguan,523129,Guangdong,China;Shenzhen Qianhai Shekou Free Trade Zone Hospital,Shenzhen 518067,Guangdong,China)
出处
《检验医学》
CAS
2022年第4期396-399,共4页
Laboratory Medicine
关键词
凝血因子Ⅴ
F5突变
凝血因子Ⅴ缺陷症
表型
基因型
Coagulation factorⅤ
F5 mutation
Coagulation factorⅤdeficiency
Phenotype
Genotype
