摘要
目的研究丙戊酸钠与左乙拉西坦治疗儿童原发性癫痫的效果及不良反应。方法选取2020年1月至2021年2月江苏省连云港市第二人民医院收治的100例儿童原发性癫痫患儿为研究对象,依据随机数字表法将其分为试验组与对照组,每组50例。对照组服用丙戊酸钠缓释片,试验组服用左乙拉西坦片。观察并比较两组治疗6个月后血药浓度、临床效果、脑电图评定结果及不良反应发生情况。结果对照组平均血药浓度为(69.73±30.15)μg/ml;试验组平均血药浓度为(13.92±4.76)mg/ml。试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。试验组脑电图纠正率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论左乙拉西坦单药治疗儿童原发性癫痫的效果优于丙戊酸钠单药治疗,且具有一定的安全性。
Objective To study the effect and adverse reactions of Sodium Valproate Sustained Release Tablets and Levetiracetam Tablets in children with primary epilepsy.Methods A total of 100 children with primary epilepsy admitted to the Second People’s Hospital of Lianyungang,Jiangsu Province from January 2020 to February 2021 were selected as the study objects.According to random number table method,they were divided into experimental group and control group,with 50 cases in each group.The control group received Sodium Valproate Sustained Release Tablets,and the experimental group received Levetiracetam Tablets.Blood drug concentration,clinical effect,electroencephalogram evaluation results,and the occurrence of adverse reactions were observed and compared between two groups after six months of treatment.Results The average blood drug concentration of control group was(69.73±30.15)μg/ml;and the average blood drug concentration of experimental group was(13.92±4.76)mg/ml.The total effective rate of experimental group was higher than that of control group,and the difference was statistically significant(P<0.05).The correction rate of electroencephalogram in experimental group was higher than that in control group,and the difference was statistically significant(P<0.05).There was no statistical difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion Levetiracetam Tablets monotherapy is superior to Sodium Valproate Sustained Release Tablets in the treatment of children with primary epilepsy,and has certain safety.
作者
陆琳
马素青
毕金珠
LU Lin;MA Suqing;BI Jinzhu(Department of Pediatrics,the Second People’s Hospital of Lianyungang,Jiangsu Province,Lianyungang 222000,China)
出处
《中国医药导报》
CAS
2022年第14期84-87,共4页
China Medical Herald
基金
江苏省自然科学基金项目(BK20180221)。
关键词
癫痫
儿童
丙戊酸钠缓释片
左乙拉西坦片
治疗
Epilepsy
Children
Sodium Valproate Sustained Release Tablets
Levetiracetam Tablets
Therapy
