摘要
目的:观察氯吡格雷联合阿司匹林治疗老年冠状动脉粥样硬化性心脏病(冠心病)患者的效果。方法:选取70例老年冠心病患者为研究对象,按照随机数字表法分为对照组和观察组各35例。对照组采用阿司匹林治疗,观察组在对照组基础上联合氯吡格雷治疗,比较两组临床疗效,治疗前后心功能指标[左心室射血分数(LVEF)、左心室舒张末内径(LVEDD)、心输出量(CO)、心脏每搏量(SV)]水平、凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)]水平,血小板聚集率及不良反应发生率。结果:观察组治疗总有效率为94.29%,高于对照组的77.14%,差异有统计学意义(P<0.05);治疗后,观察组LVEF、CO、SV水平均高于对照组,LVEDD水平低于对照组,差异有统计学意义(P<0.05);观察组PT、APTT、TT、FIB水平均低于对照组,差异有统计学意义(P<0.05);观察组血小板聚集率低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:氯吡格雷联合阿司匹林治疗老年冠心病患者,可提高临床疗效,改善患者心功能指标和凝血功能指标水平,降低血小板聚集率,其效果优于单纯阿司匹林治疗。
Objective:To observe effects of Clopidogrel combined with Aspirin in treatment of elderly patients with coronary heart disease.Methods:70 elderly patients with coronary heart disease were selected and were divided into control group and observation group according to a random number table,35 cases in each.The control group was treated with Aspirin,while the observation group was treated with Clopidogrel on the basis of that of the control group.The clinical effects,the cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),cardiac output(CO),cardiac stroke volume(SV)],the coagulation index levels[prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FIB)],the platelet aggregation rate and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 94.29%,which was higher than 77.14% in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LVEF,CO and SV in the observation group were higher than those in the control group;the level of LVEDD was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of PT,APTT,TT,and FIB in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The platelet aggregation rate in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Clopidogrel combined with Aspirin in the treatment of the elderly patients with coronary heart disease can improve the clinical effects,improve the levels of cardiac function and coagulation function indexes,and reduce the platelet aggregation rate.Moreover,it is superior to single Aspirin treatment.
作者
李娟
LI Juan(Department of Pharmacy of Xiping County People’s Hospital,Zhumadian 463900 Henan,China)
出处
《中国民康医学》
2022年第9期22-24,共3页
Medical Journal of Chinese People’s Health
关键词
氯吡格雷
阿司匹林
老年冠心病
凝血功能指标
心功能
血小板聚集率
Clopidogrel
Aspirin
Elderly coronary heart disease
Coagulation function index
Cardiac function
Platelet aggregation rate
