摘要
目的探讨认知行为疗法联合奥卡西平对癫痫患者认知功能及血清脑源性神经营养因子(BDNF)、细胞间黏附分子(ICAM-1)及胰岛素样生长因子-1(IGF-1)水平的影响。方法选取80例于2016-03—2019-03濮阳市人民医院就诊的癫痫患者,分为观察组和对照组各40例。对照组应用奥卡西平治疗,观察组在此基础上施加认知行为疗法。比较2组临床疗效、认知功能、血清BDNF、ICAM-1及IGF-1水平以及药物不良反应。结果治疗后观察组总有效率为92.50%,显著高于对照组的75.00%(P<0.05);观察组记忆、语言、执行功能等认知功能各项评分(3.91±0.12、3.45±0.41、2.95±0.45)均显著高于对照组(3.54±0.18、3.06±0.33、2.23±0.37)(P<0.05);观察组治疗后血清BDNF和IGF-1水平(1.65±0.45、145.78±13.67)高于对照组(1.32±0.73、123.25±14.01)(P<0.05),血清ICAM-1水平(30.19±4.45)低于对照组(35.35±4.73)(P<0.05);2组药物不良反应总发生率无明显差异(P>0.05)。结论认知行为疗法联合奥卡西平治疗癫痫临床疗效优于单用奥卡西平,可以显著改善患者认知功能,提高其血清中BDNF和IGF-1表达水平,降低ICAM-1表达水平。
Objective To investigate the effect of cognitive behavioral therapy combined with oxcarbazepine on cognitive function and serum levels of brain-derived neurotrophic factor(BDNF),intercellular adhesion molecule-1(ICAM-1)and insulin-like growth factor-1(IGF-1)in patients with epilepsy.Methods Eighty epilepsy patients who were treated in Puyang People’s Hospital from March 2016 to March 2019 were divided into observation group(n=40)and control group(n=40).The control group was treated with oxcarbazepine,and the observation group was treated by cognitive behavioral therapy.The clinical efficacy,cognitive function,serum BDNF,ICAM-1 and IGF-1 levels and adverse drug reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was 92.50%,which was significantly higher than that of the control group(75.00%,P<0.05).The scores of memory,language,executive function and other cognitive functions(3.91±0.12,3.45±0.41,2.95±0.45)in the observation group were significantly higher than those in the control group(3.54±0.18,3.06±0.33,2.23±0.37,P<0.05).Serum BDNF and IGF-1 levels(1.65±0.45,145.78±13.67)in the observation group after treatment were higher than those in the control group(1.32±0.73,123.25±14.01,P<0.05),serum ICAM-1 levels(30.19±4.45)was lower than the control group(35.35±4.73,P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups(P>0.05).Conclusion The clinical efficacy of cognitive behavioral therapy combined with oxcarbazepine in the treatment of epilepsy is better than that of oxcarbazepine alone,which can significantly improve the cognitive function of patients,increase the expression of BDNF and IGF-1 in serum,and reduce the expression of ICAM-1.
作者
牛智领
郭涵昫
任仙
NIU Zhiling;GUO Hanxu;REN Xian(Puyang People’s Hospital,Puyang 457000,China;The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国实用神经疾病杂志》
2022年第3期325-329,共5页
Chinese Journal of Practical Nervous Diseases
基金
河南省卫生健康委医学科技攻关计划联合共建项目(编号:LHGJ20190082)。
