奥曲肽联合乌司他丁治疗急性重症胰腺炎的安全性与疗效分析被引量：4

Analysis of the Safety and Efficacy of Octreotide Combined with Ulinastatin in the Treatment of Severe Acute Pancreatitis

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摘要目的分析急性重症胰腺炎应用奥曲肽联合乌司他丁治疗的临床效果,并探讨其安全性。方法方便选择2019年1月—2020年12月在该院进行临床治疗的急性重症胰腺炎患者(120例),利用随机抽签法分为对照组(60例)与研究组(60例),对照组对患者施以的治疗方式为奥曲肽用药,研究组对患者施以的治疗方式为奥曲肽联合乌司他丁用药,对比两组患者治疗效果。结果研究组患者临床治疗有效率、肿瘤坏死因子-α、白介素-6、白介素-8、免疫球蛋白M、免疫球蛋白A、免疫球蛋白G、D-乳酸和二胺氧化酶分别为96.66%、(58.76±9.52)μg/L、(35.81±5.92)μg/L、(46.72±4.59)μg/L、(2.01±0.43)g/L、(2.81±0.43)g/L、(13.23±1.62)g/L、(2.11±0.34)mg/L、(3.47±1.26)U/L,其各项数据与对照组对比,差异有统计学意义(χ^(2)=6.987,P=0.008;t=13.365,P<0.001;t=15.463,P<0.001;t=16.860,P<0.001;t=4.563,P<0.001;t=5.084,P<0.001;t=6.584,P<0.001;t=13.464,P<0.001;t=13.274,P<0.001)。结论奥曲肽联合乌司他丁治疗急性重症胰腺炎可明显提升患者的临床效果,改善患者炎症因子水平、免疫功能以及肠黏膜屏障功能。 Objective To analyze the clinical effect of octreotide combined with ulinastatin in the treatment of acute severe pancreatitis,and to explore its safety.Methods From January 2019 to December 2020,120 patients with acute severe pancreatitis undergoing clinical treatment in the hospital were conveniently selected.Divided into the reference group(60 cases)and the study group(60 cases)by random drawing.The treatment mode of the control group was octreotide,and the treatment mode of the study group was octreotide combined with ulinastatin.Compared the treatment effect of the two groups of patients.Results The clinical treatment effectiveness of patients in the study group,tumor necrosis factor-α,interleukin-6,interleukin-8,immunoglobulin M,immunoglobulin A,immunoglobulin G,D-lactic acid and diamine oxidase were respectively 96.66%,(58.76±9.52)μg/L,(35.81±5.92)μg/L,(46.72±4.59)μg/L,(2.01±0.43)g/L,(2.81±0.43)g/L,(13.23±1.62)g/L,(2.11±0.34)mg/L,(3.47±1.26)U/L.The data was compared with the control group,and the difference was statistically significant(χ^(2)=6.987,P=0.008;t=13.365,P<0.001;t=15.463,P<0.001;t=16.860,P<0.001;t=4.563,P<0.001;t=5.084,P<0.001;t=6.584,P<0.001;t=13.464,P<0.001;t=13.274,P<0.001).Conclusion The combination of octreotide and ulinastatin in the treatment of acute severe pancreatitis can significantly improve the clinical effect of patients,and improve the level of inflammatory factors,immune function and intestinal mucosal barrier function.

作者林杰林珊珊 LIN Jie;LIN Shanshan(The Affiliated Hospital of Putian University,Putian,Fujian Province,351100 China)

机构地区莆田学院附属医院

出处《中外医疗》 2022年第7期97-100,共4页 China & Foreign Medical Treatment

关键词急性重症胰腺炎奥曲肽乌司他丁炎症因子免疫功能 Acute severe pancreatitis Octreotide Ulinastatin Inflammatory factors Immune function

分类号 R5 [医药卫生—内科学]