摘要
总结近几年人类DUX4(double homeobox 4,DUX4)基因在细胞模型和早期胚胎基因组激活中的研究进展,发现先锋转录因子可与靶标基因的特定序列结合,诱导早期胚胎特异性染色质开放性建立及合子基因组激活(zygotic genome activation,ZGA),在母型-合子转换中发挥关键作用。探究先锋转录因子在人类早期胚胎ZGA中的作用,DUX4蛋白参与启动其他合子基因组激活基因的表达,可能是人类合子基因组激活的先锋转录因子,并对未来研究方向进行展望。
Mammalian life starts from zygote,which the oocyte is fertilized by the sperm.Subsequentmaternal-to-zygotic transition(MZT)is a crucial process in preimplantation embryo development.Pioneer transcription factors play a crucial role in the establishment of chromatin accessibility and zygotic genome activation initiation in early embryos through binding to specific sequences of target genes.However,the regulatory networks of pioneer transcription factor in human embryos remain unclear.Using the model of human embryonic stem cells,it has been found DUX4(double homeobox 4,DUX4)protein is the pivotal initiating factor for zygotic genome activation.The progress of human DUX4 in cell models and early embryo genome activation was summarized.Understanding the mechanism of zygotic genome activation in human preimplantation embryos may be helpful to optimize the in vitro culture system and to increase the success rate of assisted reproduction.
作者
刘玉兵
刘辰辰
千日成
LIU Yubing;LIU Chenchen;QIAN Richeng(Center for Reproductive Medicine,Tenth People’s Hospital of Tongji University,Shanghai 200072,China)
出处
《生物学杂志》
CAS
CSCD
北大核心
2022年第3期94-96,119,共4页
Journal of Biology
基金
国家重点研发计划项目(2017YFC1002003)
国家自然科学基金项目(31601197)。
关键词
人类胚胎
植入前胚胎发育
合子基因组激活
先锋转录因子
DUX4
human embryos
preimplantation embryo development
zygotic genome activation
pioneer transcription factor
DUX4
