摘要
目的:探讨腹腔镜右半结肠癌根治术治疗进展期右半结肠癌的效果及对患者血清结肠癌转移相关基因1(MACC1)、癌胚抗原(CEA)、糖类抗原125(CA125)水平和预后的影响。方法:选取2019年1月-2020年1月佳木斯市肛肠医院收治的64例进展期右半结肠癌患者,按照随机数字表法分为对照组与观察组,每组32例。对照组给予开腹右半结肠癌根治术,观察组给予腹腔镜右半结肠癌根治术。比较两组围术期情况,血清MACC1、CEA、CA125水平,术后1个月并发症及术后1年复发和转移情况。结果:观察组手术时间长于对照组,术中出血量、肛门排气时间、术后住院天数均少于对照组(P<0.05);但两组清扫淋巴数比较,差异无统计学意义(P>0.05)。术后5 d,两组血清MACC1、CEA、CA125水平较术前均下降,且观察组均低于对照组(P<0.05)。观察组并发症发生率为6.25%,低于对照组的28.13%(P<0.05);观察组术后1年复发率、转移率均低于对照组(P<0.05)。结论:与开腹手术相比,腹腔镜右半结肠癌根治术治疗进展期右半结肠癌有出血少、术后并发症少、恢复快等特点,且可进一步降低血清MACC1、CEA、CA125水平,减少肿瘤负荷,降低术后复发、转移风险,改善预后。
Objective:To investigate the effect of laparoscopic radical resection of right colon cancer in the treatment of advanced right colon cancer and its influence on serum metastasis-associated in colon cancer 1 (MACC1),carcinoembryonic antigen (CEA),carbohydrate antigen 125 (CA125) levels and prognosis.Method:A total of 64 patients with advanced right colon cancer admitted to Jiamusi Anorectal Hospital from January 2019 to January 2020 were selected and divided into the control group and the observation group according to the random number table method,32 cases in each group.The control group was given open radical resection of the right colon cancer,and the observation group was given laparoscopic radical resection of the right colon cancer.The perioperative conditions,serum MACC1,CEA,CA125 levels,complications 1 month after operation and recurrence and metastasis 1 year after operation of two groups were compared.Result:The operation time of the observation group was longer than that of the control group,and the amount of intraoperative blood loss,anal exhaust time,and postoperative hospital stay were less than those of the control group (P<0.05);but there was no significant difference in the number of lymph nodes removed between two groups (P>0.05).At 5 d after operation,the serum levels of MACC1,CEA,and CA125 in two groups were lower than those before operation,and the observation group were lower than those of the control group (P<0.05).The complication rate in the observation group was 6.25%,which was lower than 28.13% in the control group (P<0.05).The recurrence rate and metastasis rate 1 year after operation in the observation group were lower than those in the control group (P<0.05).Conclusion:Compared with open surgery,laparoscopic radical resection of right colon cancer in the treatment of advanced right colon cancer has the characteristics of less bleeding,less postoperative complications,faster recovery,and can further reduce serum MACC1,CEA,CA125 levels,reduce tumor load,reduce the risk of postoperative recurrence and metastasis,and improve the prognosis.
作者
孙玉磊
SUN Yulei(Jiamusi Anorectal Hospital Heilongjiang Province)
出处
《中国医学创新》
CAS
2022年第14期34-38,共5页
Medical Innovation of China
关键词
腹腔镜
右半结肠癌根治术
进展期
右半结肠癌
结肠癌转移相关基因1
癌胚抗原
糖类抗原125
Laparoscopy
Radical resection of right colon cancer
Advanced
Right colon cancer
Metastasis-associated in colon cancer 1
Carcinoembryonic antigen
Carbohydrate antigen 125
