摘要
中药在炮制过程中会发生复杂的化学物质变化,而如何辨识这些变化是中药炮制机制研究的关键科学问题。进入21世纪的20多年来,中药炮制中对化学物质变化的研究不仅关注炮制过程中化学物质的变化,更加注重化学物质在生物药剂学过程中的改变。随着信息技术的发展,各种化学物质辨识技术(仪器分析技术、分子生物学技术、数据挖掘技术、微生物转化技术)得到快速发展,并在炮制机制研究中广泛应用。基于此,笔者通过梳理中药炮制机制研究中化学物质辨识的关键技术,提出以“炮制过程-生物药剂学过程”中化学物质变化为基础,以多模态辨识为核心的研究策略,旨在构建一种跨学科、跨方位、跨维度的中药炮制机制研究模式,深入揭示中药炮制机制的科学内涵。
Chinese medicine undergoes complex chemical changes during processing and identifying these changes is the key to the processing mechanism.In the past 20 years of the 21 st century,research on the chemical changes in Chinese medicine after processing has focused the changes in the biopharmaceutical process in addition to the variation during processing.With the surging of information technologies,various identification technologies(instrumental analysis techniques,molecular biological techniques,data mining techniques,and biotransformation techniques)have developed rapidly and been widely applied to the research on processing mechanism.Thus,based on the chemical changes in the processing and biopharmaceutical process,the author suggested a research tactic of multimodal identification as the core by reorganizing key technologies for chemical identification from studies of the processing mechanism of Chinese me-dicine,aiming at establishing an interdisciplinary multi-dimensional research model for the processing mechanism of Chinese medicine.
作者
郭舒臣
梁士魁
李得天
杨冰
封亮
贾晓斌
GUO Shu-chen;LIANG Shi-kui;LI De-tian;YANG Bing;FENG Liang;JIA Xiao-bin(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第5期1153-1160,共8页
China Journal of Chinese Materia Medica
基金
国家重点研发计划项目(2018YFC1706900)
国家自然科学基金项目(81573620)
中国药科大学双一流建设创新团队项目(CPU2018GY11)。
关键词
中药炮制机制
化学变化
炮制过程
生物药剂学过程
多模态辨识
mechanism of Chinese medicinal processing
chemical changes
processing process
biopharmaceutical process
multimodal identification
