摘要
胶质肉瘤(gliosarcoma,GSM)是胶质母细胞瘤(glioblastoma,GBM)的一种类型,后者是胶质瘤病理WHO分级中恶性程度最高的(WHOⅣ级)。GSM的特征是其组织中含有双重成分:胶质瘤成分和肉瘤成分。GSM分为原发性和继发性2种亚型。GSM通常通过手术全切除、放疗、合并或不合并化疗来处理,但治疗效果尚不确切。其治疗方案与GBM病例相似,但在两者之间可产生不同的治疗结果。由于GSM整体病例较少,目前对GSM研究比较缺乏,将来需要更多的病例研究。本综述总结GSM的生物学特征、影像学表现、治疗方法及预后等。
Gliosarcoma(GSM)is a variant of glioblastoma(GBM),which is the most malignant subtype glioma in the WHO pathological grade(WHO gradeⅣ).The characteristic of GSM is that its tissue contains two components:glioma and sarcoma.GSM is divided into two subtypes:primary and secondary.GSM is usually treated by total surgical resection,radiotherapy,with or without chemotherapy,but the therapeutic effect is not exact.It is reported that the treatment scheme is similar to that of GBM cases,but with different treatment outcomes.This review summarizes the biological characteristics,imaging findings,treatment and prognosis of GSM cases.
作者
许珏凤
徐荣
XU Jue-feng;XU Rong(Department of Operation Room,Huashan Hospital,Fudan University,Shanghai 200040,China;Department of Neurosurgery,Huashan Hospital,Fudan University,Shanghai 200040,China)
出处
《中国临床医学》
2022年第3期499-503,共5页
Chinese Journal of Clinical Medicine
基金
上海市科学技术委员会基金(19140900105).
关键词
胶质肉瘤
基因突变
放疗
化疗
预后
gliosarcoma
genomic alternation
radiotherapy
chemotherapy
prognosis
