摘要
目的观察蒲苓盆炎康颗粒联合西医治疗慢性盆腔炎(CPID)湿热瘀结证的临床疗效及对患者血清炎症指标和血液流变学指标的影响。方法选择2020年1月至2021年12月山东省济宁市第一人民医院妇科CPID湿热瘀结证门诊患者106例,按照随机数字表法分为治疗组和对照组,各53例。对照组给予左氧氟沙星注射液联合甲硝唑注射液静脉滴注治疗,治疗组在对照组治疗基础上联合蒲苓盆炎康颗粒口服治疗。比较2组中医证候积分、血清炎症指标[超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、白细胞介素10(IL-10)、肿瘤坏死因子α(TNF-α)]、血液流变学指标[全血黏度(低切、中切、高切)、血浆黏度、红细胞比容、纤维蛋白原],统计临床疗效。结果①治疗过程中,治疗组脱落2例,对照组脱落、剔除4例,最终完成试验100例,治疗组51例,对照组49例。②2组治疗后中医证候各项评分及总分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组治疗后(P<0.05)。③2组治疗后血清hs-CRP、IL-6、TNF-α含量均较本组治疗前降低(P<0.05),IL-10含量升高(P<0.05),且治疗组治疗后血清hs-CRP、IL-6、TNF-α含量低于对照组(P<0.05),IL-10含量高于对照组(P<0.05)。④2组治疗后全血黏度(低切、中切、高切)、血浆黏度、纤维蛋白原、红细胞比容均低于本组治疗前(P<0.05),且治疗组治疗后全血黏度(低切、中切、高切)、血浆黏度、纤维蛋白原、红细胞比容均低于对照组治疗后(P<0.05)。⑤治疗组总有效率92.16%(47/53),对照组75.51%(38/53),治疗组疗效优于对照组(χ^(2)=4.181,P<0.05)。结论蒲苓盆炎康颗粒联合西医常规治疗能够改善CPID湿热瘀结证患者临床症状,提高治疗效果,可能与拮抗炎性反应、改善血液流变学等因素有关。
Objective To observe the clinical efficacy of Puling Penyankang Granule combined with Western medicine on chronic pelvic inflammatory disease(CPID)with dampness heat stasis syndrome and its effect on serum inflammatory indexes and hemorheology.Methods Totally 106 CPID patients(damp heat stasis syndrome)admitted to the Department of Gynecology,Jining No.1 People's Hospital from January 2020 to December 2021 were randomly divided into the treatment group and the control group,with 53 cases in each group.The control group was treated with levofloxacin combined with metronidazole intravenous drip,and the treatment group was treated with Puling Penyankang Granule on the basis of the control group.The TCM syndrome score,serum inflammatory indexes(high-sensitivity C-reactive protein[hs-CRP],interleukin-6[IL-6],interleukin-10[IL-10]and tumor necrosis factor-α)in groups were compared.tumor necrosis factor-α[TNF-α],hemorheology(whole blood viscosity[WBV]at high,medium and low shear rates,plasma viscosity,hematocrit,fibrinogen),the clinical efficacy was statisted.Results During the treatment,2 cases fell off in the treatment group,4 cases fell off in the control group,and 100 cases finally completed the test,51 cases in the treatment group and 49 cases in the control group.The scores of TCM syndromes in groups after treatment were lower(P<0.05),and the treatment group was common(P<0.05).After treatment,the levels of serum hs-CRP,IL-6 and TNF-αin both groups were lower than those before treatment in the same group,while the levels of IL-10 increased(P<0.05);decreased hs-CRP,IL-6,TNF-αcontent and increased IL-10 content in the treatment were found compared with the control group(all P<0.05).WBV at high,medium and low shear rates,plasma viscosity,fibrinogen and hematocrit after treatment in groups were lower(P<0.05),and which were lower in the treatment group than the control group(P<0.05).The overall effective rate in the treatment group was better than that in the control group(92.16%[47/53]vs 75.51%[38/53],[χ^(2)=4.181,P<0.05],respectively).Conclusion For CPID patients(damp heat stasis syndrome),Puling Penyankang Granule combined with Western medicine can improve the clinical symptoms by inhibiting antagonistic inflammatory response and improving blood rheology and other factors.
作者
周静
王长河
ZHOU Jing;WANG Changhe(Department of Gynecology,Jining No.1 People's Hospital,Jining,Shandong 272000)
出处
《河北中医》
2022年第3期441-445,共5页
Hebei Journal of Traditional Chinese Medicine
关键词
盆腔炎性疾病
湿热下注
血瘀
中西医结合疗法
Pelvic inflammatory disease
Damp invasion of lower energizer
Blood stasis
Integrated traditional Chinese and Western medicine therapy
