摘要
目的 探讨细菌性阴道炎患者激素水平与阴道分泌物检测指标的相关性.方法 2020年1月至2021年6月曾在本院就诊的具有阴道炎临床症状的女性患者127例为观察组,同期体检中心检查的健康女性83例为对照组.所有受试者在月经干净3~7 d采集阴道分泌物,当日采集两组患者空腹静脉血5 mL于含促凝剂管中,3,000 r/min离心10 min,收集血清,用于性激素的检测.结果 细菌性阴道炎患者阴道分泌物清洁度Ⅲ度及Ⅳ度的检出率明显高于对照组(P<0.05);细菌性阴道炎患者过氧化氢浓度<2、白细胞酯酶及线索细胞阳性检出率均明显高于对照组(P<0.05).细菌性阴道炎组患者的血清雌二醇(E2)、孕酮(PROG)、睾酮(TESTO)水平均显著低于对照组(P<0.05).阴道清洁度与其睾酮激素、孕酮激素水平呈负相关(r=-0.225,P=0.031;r=-0.267,P=0.010).结论 阴道炎患者性激素水平和阴道清洁度存在一定的内在联系,性激素水平的变化可能参与阴道微生态失调的发生.在女性阴道分泌物检测的同时,血清性激素的水平可以辅助临床医师对阴道微环境的状态把握与判断.
Objective To explore the correlation between the hormone levels of vaginitis patients and the detection indicators of vaginal secretions.Methods 127 female patients with clinical symptoms of vaginitis who were in the hospital from January 2020 to June 2021 were included in the observation group,and 83 healthy women who were included in the physical examination center during the same period were included in the control group.The vaginal secretions of all subjects were collected during clean nienstmation 3~7 days.On the same day,5 mL of fasting venous blood were collected from two groups of patients in a tube containing a coagulant,centrifuged at 3,000 rpm for 10 minutes,and the serum was collected for the detection of sex hormones.Results The detection rate of vaginal secretion cleanliness Ⅲ and Ⅳ in patients with bacterial vaginitis was significantly higher than that of the control group(P<0.05),the patients of Bacterial vaginitis with hydrogen peroxide concentration<2,the positive detection rate of white blood cell esterase and clue cells were significantly higher than the control group(P<0.05).The E2,PROG,and TESTO levels in semm of the patients in the bacterial vaginitis group were significantly lower than those in the control group(P<0.05).The cleanliness of the vagina was positively correlated with the levels of testosterone hormone and progesterone hormone(r=-0.225,P=0.031,r=-0.267,P=0.010),and other sex hormone index statistics did not show correlation.Conclusion There is a certain internal relationship between sex hormone levels and vaginal cleanliness in patients with vaginitis.It is considered that changes in sex hormone levels may be involved in the occurrence of vaginal niicroecological disorders.In the detection of female vaginal secretions,the level of serum sex hormones can assist clinicians to grasp and judge the state of the vaginal microenvironment.
出处
《浙江临床医学》
2022年第5期727-728,731,共3页
Zhejiang Clinical Medical Journal
关键词
细菌性阴道炎
性激素
阴道清洁度
Bacterial vaginitis
Sex hormones
Vaginal cleanliness
