摘要
目的 探讨养阴益气汤对冠状动脉粥样硬化性心脏病心绞痛患者血管内皮因子及血脂的影响。方法 选取2019年3月至2020年3月于抚顺市中医院心病科住院治疗的冠状动脉粥样硬化性心脏病心绞痛患者64例作为研究对象,根据住院病例号随机分为西药组与中西医结合组,各32例。两组患者进行抗血小板聚集、营养心肌、稳定斑块等对症治疗。西药组患者同时予以硝酸甘油注射液治疗,中西医结合组患者在对照组基础上联合口服养阴益气汤治疗。比较两组患者治疗前后高密度脂蛋白、低密度脂蛋白、一氧化氮(NO)、内皮素(ET)及视觉模拟评分法(VAS)评分,治疗有效率及硝酸甘油停减率。结果 治疗后,西药组及中西医结合组高密度脂蛋白、NO水平较治疗前升高,低密度脂蛋白、ET水平、VAS评分较治疗前降低,且中西医结合组改变程度更显著,差异有统计学意义(P<0.05)。治疗后,中西医结合组治疗有效率为90.63%,西药组治疗有效率为65.63%,中西医结合组治疗有效率明显高于西药组(P<0.05)。治疗后,西药组甘油停减率为65.63%,中西医结合组甘油停减率为93.75%,中西医结合组显著高于西药组(P<0.05)。结论 养阴益气汤具有缓解冠状动脉痉挛、抑制冠状动脉血栓斑块形成、修复血管内皮结构、改善冠状动脉供血、平衡内皮因子水平等作用,可减轻冠状动脉粥样硬化性心脏病心绞痛、胸闷、胸痛等症状。
Objective T To explore the effects of Yangyin Yiqi Decoction on vascular endothelial factors and blood lipids in patients with coronary heart disease and angina pectoris. Methods A total of 64 patients with coronary heart disease and angina pectoris hospitalized in the Cardiology Department of Fushun Hospital of Traditional Chinese Medicine from March 2019 to March 2020 were selected as the research object. According to the inpatient case number, they were randomly divided into Western medicine group and integrated traditional Chinese and Western medicine group, with 32 cases in each group. The 2 groups were treated with antiplatelet aggregation, myocardial nutrition and plaque stabilization. The patients in the Western medicine group were treated with nitroglycerin injection at the same time, and the patients in the integrated traditional Chinese and Western medicine group were treated with Yangyin Yiqi Decoction on the basis of the control group. High density lipoprotein, low density lipoprotein,nitric oxide(no), endothelin(ET) and the scores of visual analogue scale(VAS) were compared between the 2 groups before and after treatment.The effective rate and nitroglycerin reduction rate of the two groups were compared. Results After treatment, the levels of high-density lipoprotein and NO in the Western medicine group and the integrated traditional Chinese and Western medicine group were higher than before the treatment, and the levels of low-density lipoprotein, ET, and VAS score were all lower than before the treatment, and the degree of change in the integrated traditional Chinese and Western medicine group was more significant. The difference was statistically significant(P<0.05). After treatment, the effective rate of treatment in the Western medicine group was 65.63%, the effective rate in the integrated traditional Chinese and Western medicine group was 90.63%, and the effective rate of the integrated traditional Chinese and Western medicine group was significantly higher than that in the Western medicine group(P<0.05). After treatment, the rate of glycerol reduction in the Western medicine group was 65.63%, and the rate of glycerol reduction in the integrated traditional Chinese and Western medicine group was 93.75%, which was significantly higher than that in the Western medicine group(P<0.05). Conclusion Yangyin Yiqi Decoction can relieve coronary artery spasm, inhibit coronary thrombotic plaque formation, repair vascular endothelial structure, improve coronary blood supply, balance endothelial factor levels, etc., and alleviate symptoms of coronary heart disease, angina, chest tightness, chest pain and other symptoms.
作者
杨兴隆
安桐志
YANG Xing-Long;AN Tong-Zhi(Department of Cardiology,Fushun Hospital of Traditional Chinese Medicine,Fushun 113008,China)
出处
《中国药物经济学》
2022年第4期59-63,共5页
China Journal of Pharmaceutical Economics
