摘要
目的:分析妊娠合并梅毒患者抗梅毒不同治疗时机对妊娠结局的影响及相关因素.方法:回顾性收集本院2018年12月-2020年5月治疗的妊娠合并梅毒125例临床资料,根据驱梅毒介入时间分成早期组(孕<13周,31例)、中期组(孕13~28周,35例)、晚期组(孕>28周,48例)以及未治疗组,介入治疗药物主要是G240万U苄星青霉素,比较各组不良妊娠情况及影响因素.结果:各组发生早产、死胎、流产、低体重儿几率无差异(P>0.05),但发生先天梅毒儿存在差异,各组分别为早期组(6.5%)、中期组(31.4%)、晚期组(31.3%)、未治疗组(9.5%)(P<0.05).二元logistics回归分析,影响妊娠合并梅毒发生不良结局危险因素主要是孕前频繁不洁性生活、免疫力低下,相关系数分别为0.198、0.262(P<0.05).结论:妊娠合并梅毒不同时机治疗对妊娠结局有影响,早期治疗优于中晚期,提示临床应做好孕前梅毒筛查,做到早发现、早治疗.
Objective: To study the influences of different treatment timing of antisyphilitic therapy of pregnant women on their pregnancy outcomes, and to analysis the related factors. Methods: The clinical data of 125 pregnant women with syphilis between December 2018 and May 2020 were collected retrospectively. The antisyphilitic infection of these women was treated by G240 U benzathine penicillin. These women were divided into group A(31 women with antisyphilitic therapy during <13 gestational weeks), group B(35 women with antisyphilitic therapy during 13 to 28 gestational weeks), group C(48 women with antisyphilitic therapy during >28 gestational weeks), and group D(11 women without antisyphilitic therapy). The adverse pregnancy situations and the influence factors of adverse pregnancy outcomes of the women were compared among the four groups. Results: There were no significant differences in the incidents of preterm birth, stillbirth, abortion, and low birth weight of the women among the four groups(P>0.05), but the incidences of congenital syphilis in group A, group B, group C, and group D were 6.5%, 31.4%, 31.3%, and 9.5%, respectively, which had significantly different among the four groups(P<0.05). Binary logistic regression analysis showed that the main risk factors of severe adverse pregnancy outcomes of the pregnant women complicated with syphilis included their frequent unsafe sex life before pregnancy and their low immunity, and Kendall’s correlation coefficient of the severe adverse pregnancy outcomes of the women with their frequent unsafe sex life before pregnancy and their low immunity were 0.198 and 0.262(P<0.05). Conclusion: Different treatment timing of antisyphilitic therapy of the pregnant women influence their pregnancy outcomes and the early antisyphilitic therapy is better than late antisyphilitic therapy, which suggests it is necessary to screen pre-pregnancy syphilis, and early detection and early treatment of pregnancy complicated with syphilis of the pregnant women should be conducted.
作者
荆玉慧
李玲
杨露
位菊峰
JING Yuhui;LI Ling;YANG Lu;WEI Jufeng(Qingdao Central Hospital,Qingdao,Shandong Province,266034)
出处
《中国计划生育学杂志》
2022年第7期1659-1663,共5页
Chinese Journal of Family Planning
基金
青岛市2019年度医药科研指导计划立项(2019-WJZD059)。
关键词
妊娠合并梅毒
治疗时机
不良妊娠结局
影响因素
Pregnancy complicated with syphilis
Treatment timing
Adverse pregnancy outcome
Influence factor
