摘要
目的:探讨参附注射液辅助治疗重型颅脑损伤(SCI)行开颅手术患者的效果。方法:按随机数字表法将内江市第一人民医院2018年1月-2019年12月收治的行开颅手术治疗的60例SCI患者分为对照组30例(术后常规治疗)与参附组30例(在对照组基础上加用参附注射液)。对比两组格拉斯哥昏迷指数(GCS)及甘露醇使用天数、血清S100β蛋白及神经元特异性烯醇化酶(NSE)水平、并发症、术后6个月预后情况。结果:参附组甘露醇使用天数及术后意识觉醒时间均短于对照组(P<0.05);术后7、14、28 d,两组GCS评分均升高,且参附组均高于对照组(P<0.05)。术前,两组血清S100β蛋白、NSE水平对比,差异均无统计学意义(P>0.05);术后24、48、72 h,两组S100β蛋白、NSE水平均降低,且参附组均低于对照组(P<0.05)。两组并发症发生率对比,差异无统计学意义(P>0.05)。参附组格拉斯哥预后(GOS)评分高于对照组(P<0.05)。结论:参附注射液辅助治疗SCI可有效减轻脑组织损伤,促进患者术后意识恢复,改善短期预后,并能减少甘露醇的使用,但减少并发症的效果有限。
Objective:To investigate the effect of Shenfu injection in the adjuvant treatment of severe craniocerebral injury(SCI)patients undergoing craniotomy.Method:According to the random number table method,60 SCI patients who were treated by craniotomy in the First People’s Hospital of Neijiang from January 2018 to December 2019 were divided into the control group of 30(conventional treatment after operation)and the Shenfu group of 30(Shenfu Injection was added on the basis of the control group).The wakefulness-related indicators,days of Mannitol use,serum S100βprotein and neuron specific enolase(NSE)levels,complications,and 6-month postoperative prognosis were compared between the two groups.Result:The Mannitol use days and postoperative consciousness awakening time in the Shenfu group were shorter than those in the control group(P<0.05).At 7,14,and 28 d after operation,the GCS scores of two groups were increased,and the Shenfu group were higher than those of the control group(P<0.05).Before surgery,there were no significant differences in the serum S100βprotein and NSE levels between two groups(P>0.05);at 24,48 and 72 h after operation,the S100βprotein and NSE levels in two groups were decreased,and the Shenfu group were lower than those of the control group(P<0.05).There was no significant difference in the incidence of complications between two groups(P>0.05).The GOS score of Shenfu group at 6 months after surgery was higher than that of the control group(P<0.05).Conclusion:Adjuvant Shenfu Injection in the treatment of SCI can effectively reduce brain tissue damage,promote postoperative recovery of consciousness,improve short-term prognosis,and reduce the use of mannitol,but the effect of reducing complications is limited.
作者
卢玺宇
田伟
吴爱玲
刘丛
LU Xiyu;TIAN Wei;WU Ailing;LIU Cong(The First People’s Hospital of Neijiang,Sichuan Province,Neijiang 641000,China;不详)
出处
《中国医学创新》
CAS
2022年第20期126-129,共4页
Medical Innovation of China
基金
内江市科技计划项目(Z201951)。
