摘要
目的探讨尼莫地平联合替罗非班对颅内动脉瘤介入栓塞术中急性血栓事件的有效性与安全性。方法52例进行颅内动脉瘤介入栓塞术治疗的患者,采用随机数字法分为观察组与对照组,各26例。观察组实施尼莫地平联合替罗非班治疗,对照组实施阿司匹林联合氯吡格雷治疗。比较两组头颅动脉瘤造影结果及颅内出血、血栓栓塞发生情况。结果52例患者中,共发现动脉瘤62枚,其中观察组31枚,对照组31枚。瘤直径范围1.5~15 mm,平均直径(6.2±1.1)mm。两组各动脉瘤位置比较,差异无统计学意义(P>0.05)。两组术后颅内出血发生率、术中栓塞发生率比较,差异无统计学意义(P>0.05);观察组术后栓塞发生率11.52%低于对照组的46.15%,差异有统计学意义(P<0.05)。结论针对颅内动脉瘤介入栓塞术治疗患者,尼莫地平联合替罗非班效果显著,且能够有效预防围术期栓塞的发生,值得临床应用。
Objective To discuss the efficacy and safety of nimodipine combined with tirofiban for acute thromboembolic events during interventional embolization of intracranial aneurysms.Methods A total of 52 patients who underwent interventional embolization of intracranial aneurysm were divided into observation group and control group by random numerical table,with 26 cases in each group.The observation group was treated with nimodipine combined with tirofiban,and the control group was treated with aspirin combined with clopidogrel.The angiography results of head aneurysms,intracranial hemorrhage and occurrence of embolism of the two groups were compared..Results Among the 52 patients,a total of 62 aneurysms were found,including 31 aneurysms in the observation group and 31 aneurysms in the control group.The aneurysm diameters ranged from 1.5 to 15 mm,with a mean diameter of(6.2±1.1)mm.there was no statistically significant difference in the location of each aneurysm between the two groups(P>0.05).There was no statistically significant difference in the incidence of intracranial hemorrhage and intraoperative embolism between the two groups(P>0.05).The incidence of postoperative embolism 11.52%in the observation group was lower than 46.15%in the control group,and the difference was statistically significant(P<0.05).Conclusion Nimodipine combined with tirofiban is effective in the treatment of patients undergoing interventional embolization of intracranial aneurysms,and can effectively prevent the occurrence of perioperative embolism.It is worthy of clinical application.
作者
孙丰兵
丁培源
张健
孟佑强
黄盛
游轶杰
SUN Feng-bing;DING Pei-yuan;ZHANG Jian(Chongming Branch of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 202150,China)
出处
《中国现代药物应用》
2022年第11期16-19,共4页
Chinese Journal of Modern Drug Application
关键词
尼莫地平
替罗非班
颅内动脉瘤介入栓塞术
急性血栓事件
有效性
安全性
Nimodipine
Tirofiban
Interventional embolization of intracranial aneurysms
Acute thromboembolic events
Efficacy
Safety
