摘要
目的:分析磁共振动态增强扫描成像(DCE-MRI)与血清肝细胞生长因子(HGF)受体c-Met、结肠癌转移相关基因1(MACC1)联合检测对宫颈癌(CC)盆腔淋巴结转移的诊断价值。方法:选取医院收治的124例CC患者,根据其发生盆腔淋巴结转移与否分为淋巴结未转移组(88例,简称未转移组)和淋巴结转移组(36例,简称转移组)。所有患者均行DCE-MRI检查、血清c-Met及MACC1水平检测;以患者术后组织病理学检查为“金标准”,分析DCE-MRI检查、血清c-Met、MACC1检测及三者联合诊断对CC患者盆腔淋巴结转移的诊断效能。结果:转移组中DCE-MRI评估患者盆腔淋巴结转移的灵敏度为77.78%,特异度为93.18%,准确度为88.71%;血清c-Met及MACC1水平均高于未转移组,差异有统计学意义(t=10.466,t=9.267;P<0.05);血清c-Met和MACC1诊断盆腔淋巴结转移的受试者工作特征(ROC)曲线下面积(AUC)分别为0.893和0.879,截断值分别为104.23μg/L和6.70 ng/ml,灵敏度、特异度分别为83.33%和80.56%,89.77%和90.91%,准确率均为87.90%;DCE-MRI与血清c-Met、MACC1联合诊断患者盆腔淋巴结转移的灵敏度及准确率分别为94.44%和90.32%,均高于三者单独检测,差异有统计学意义(x^(2)=4.181,P<0.05)。结论:DCE-MRI联合血清c-Met、MACC1检测对CC盆腔淋巴结转移有较高的诊断价值,三者联合可显著提高灵敏度,有助于临床判定CC盆腔淋巴结转移。
Objective:To analyze the diagnostic value that dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)combined with serum hepatocyte growth factor(HGF)receptor c-Met and metastasis-associated in colon cancer 1(MACC1)for pelvic lymph node metastasis of cervical cancer(CC).Methods:A total of 124 CC patients admitted to hospital were selected as the research subjects.They were divided into lymph node non-metastasis group(88 cases)and lymph node metastasis group(36 cases)according to whether occurred pelvic lymph node metastasis.All CC patients underwent DCE-MRI examination,serum c-Met and MACC1 detection.The histopathological examination after surgery for CC patients was used as golden standard to analyze the diagnostic efficiencies of DCE-MRI examination,serum c-Met detection,serum MACC1 detection and the combined diagnosis of above three methods for pelvic lymph node metastasis of CC patients.Results:The sensitivity,specificity and accuracy of DCE-MRI of lymph node metastasis group were 77.78%,93.18%and 88.71%in assessing pelvic lymph node metastasis of CC patients,and the levels of serum c-Met and MACC1 of metastasis group were significantly higher than those of non-metastasis group(t=10.466,t=9.267,P<0.05).The area under the curve(AUC)of receiver operating characteristics(ROC)of serum c-Met and MACC1 were 0.893 and 0.879,respectively,in diagnosing pelvic lymph node metastasis,and the cut-off values of them were 104.23μg/L and 6.70 ng/mL,respectively.In addition,the sensitivities and specificities of them were(83.33%and 80.56%)and(89.77%and 90.91%),respectively,and the accuracies both them were 87.90%.The sensitivity and accuracy of the combined diagnosis of DCE-MRI and serum c-Met and MACC1 were 94.44%and 90.32%in diagnosing pelvic lymph node metastasis of CC patients,respectively,and both of them were significantly higher than those of each single detection(x^(2)=4.181,P<0.05).Conclusion:The detection of DCE-MRI combined with serum c-Met and MACC1 has higher diagnostic value for pelvic lymph node metastasis of CC patients.The combination of the three methods can significantly improve the sensitivity and help to clinically determine pelvic lymph node metastasis of CC patients.
作者
张梯勇
陈文
陈晓雷
舒源河
ZHANG Ti-yong;CHEN Wen;CHEN Xiao-lei(不详;Department of Radiology,Qianjiang Central Hospital of Chongqing,Chongqing 409000,China)
出处
《中国医学装备》
2022年第7期58-62,共5页
China Medical Equipment
基金
重庆市卫生健康委员会科研项目(2019HBRC016)“磁共振功能成像在宫颈癌检测中的应用研究价值”。
