摘要
目的 探究葡萄糖六磷酸脱氢酶(G6PD)活性检测在地中海贫血诊断中的临床价值。方法 选择2019年10月-2020年12月在本院行G6PD活性检测的200例受检者,根据其健康状况或疾病类型分为健康体检组(n=20)、地贫组(n=138)、缺铁贫血组(n=42),比较各组G6PD活性的差异,并绘制ROC曲线分析G6PD活性诊断地贫的临床效能。结果 地贫组的G6PD活性显著高于缺铁贫血组、健康体检组(P<0.05)。而且在地贫组中,不同贫血程度患者其G6PD活性的差异有统计学意义(P<0.05)。经ROC曲线发现,G6PD活性诊断地贫的灵敏度72.50%,特异性71.00%。结论 地贫患者G6PD活性显著升高,且贫血程度越严重G6PD活性越高,其对于地贫诊断具有良好的灵敏度和特异性,有一定的辅助诊断价值,予以推广应用。
Objective To explore the clinical value of glucose hexaphosphate dehydrogenase(G6PD)activity in the diagnosis of thalassemia. Methods 200 subject of G6PD activity tested in our hospital from October 2019 to December 2020 were divided into physical examination group(n =20), thalassemia group(n =138) and iron deficiency anemia group(n =42) according to their health status or disease type. The differences of G6PD activity in each group were compared, and the ROC curve was drawn to analyze the clinical efficacy of G6PD activity in the diagnosis of thalassemia. Results The G6PD activity of simple thalassemia group was significantly higher than iron deficiency anemia group and health examination group(P <0.05). Moreover, in the thalassemia group, there was significant difference in G6PD activity in patients with different degrees of anemia(P <0.05). The ROC curve showed that the sensitivity and specificity of G6PD activity in the diagnosis of thalassemia were 72.50% and 71.00%. Conclusion The G6PD activity in patients with thalassemia is significantly increased, and the more severe the anemia is,the higher the G6PD activity is. It has high sensitivity and specificity for the diagnosis of thalassemia, and has certain auxiliary diagnostic value, which should be popularized and applied.
作者
罗秀霞
沈诚
LUO Xiuxia;SHEN Cheng(Department of Clinical Laboratory,the People's Hospital of Hengli Town,Dongguan,Guangdong 523000)
出处
《智慧健康》
2022年第10期1-3,共3页
Smart Healthcare
