摘要
目的:探讨宫腔镜电切术联合孕激素对子宫内膜息肉患者的疗效,并分析性激素水平与疾病复发的相关性。方法:根据治疗方案不同将106例子宫内膜息肉患者分为研究组(n=57)及对照组(n=49);两组患者均行宫腔镜电切术治疗,研究组联合孕激素治疗。分析两组术前及术后3、6、12个月每月经期时间、月经量、子宫内膜厚度;检测血清雌二醇(E2)、黄体生成素(LH)及卵泡生成素(FSH)及血红蛋白(Hb)水平;随访12个月,分析术后不良反应、不孕患者妊娠、子宫息肉复发情况及疗效评价。结果:研究组及对照组术后各时间点、各指标水平均低于术前(P<0.05);术后6个月,研究组月经量与对照组比较,差异无统计学意义(P>0.05),但在各术后3、6、12个月经期长度、月经量、子宫内膜厚度、血清E2、LH、FSH水平均低于治疗前及对照组,Hb水平高于治疗前及对照组(P<0.05);研究组治疗总有效率高于对照组(P<0.05);研究组不孕患者术后妊娠率高于对照组(P<0.05);研究组术后12个月内累计复发率低于对照组(P<0.05);E2、LH及FSH高表达与患者术后复发具有相关性(P<0.05)。结论:宫腔镜电切术联合孕激素对子宫内膜息肉患者的治疗效果较理想,各临床症状及相关血清学指标均显著改善;通过监测患者术后血清E2、LH、FSH水平结合临床症状,及时采取预防或治疗措施,可有效降低术后复发率。
Objective:To explore the curative effect of hysteroscopy electrotomy combined with progesterone on patients with endometrial polyps,and to analyze the correlation between sex hormone levels and disease recurrence.Methods:A total of 106 patients with endometrial polyps divided into study group(n=57)and control group(n=49)according to different treatment schemes.Patients in both groups were treated with hysteroscopic electroresection,and the study group was treated with progesterone.The menstrual time,menstrual volume and endometrial thickness were recorded before operation and 3,6 and 12 m after operation,and the levels of serum estradiol(E2),luteinizing hormone(LH),follicle-producing hormone(FSH)and hemoglobin(Hb)were measured.The adverse reactions,pregnancy,recurrence of uterine polyps and curative effect evaluation were analyzed after 12 m follow-up.Results:The postoperative time points and index levels in the study group and the control group were significantly lower than those before the operation(P<0.05).6 m after the operation,there was no difference between the study group and the control group(P>0.05).The menstrual period length,menstrual volume,endometrial thickness,serum E2,LH,and FSH levels in the study group were lower than those before treatment and the control group at 3,6 and 12 m after operation,and the Hb level was higher than those before treatment and the control group(P<0.05).The total effective rate of the research group was higher than that of the control group(P<0.05),the postoperative pregnancy rate of infertile patients in the research group was higher than that of the control group(P<0.05).The cumulative recurrence rate within 12 m after operation in the study group was lower than that of the control group(P<0.05).The high expression E2,LH,FSH was correlated with postoperative recurrence(P<0.05).Conclusion:Hysteroscopic resection combined with progesterone has an ideal therapeutic effect on patients with endometrial polyps,and all clinical symptoms and related serological indicators have been significantly improved,in addition,it may be possible to monitor the postoperative serum E2,LH,and FSH levels in combination with clinical symptoms.Take preventive or therapeutic measures to reduce postoperative recurrence rate.
作者
黄超英
黄英莲
张艺英
秦小欢
蒙彩金
HUANG Chao-ying;HUANG Ying-lian;ZHANG Yi-ying;QIN Xiao-huan;MENG Cai-jin(Department of Gynecology,Guiping People's Hospital,Guigang 537200,Guangxi,China)
出处
《川北医学院学报》
CAS
2022年第7期861-865,共5页
Journal of North Sichuan Medical College
基金
广西壮族自治区卫生健康委员会自筹经费科研项目(Z20201176)。
关键词
子宫内膜息肉
宫腔镜电切术
孕激素
性激素
复发
Endometrial polyps
Hysteroscopic resection
Progesterone
Sex hormones
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