摘要
目的探讨特瑞普利单抗治疗胃腺癌患者致中毒性表皮坏死松解症的治疗策略。方法分析1例特瑞普利单抗致中毒性表皮坏死松解症患者的治疗经过,结合文献探讨免疫治疗相关的中毒性表皮坏死松解症的发生机制、一般特点及治疗方法。结果患者在应用特瑞普利单抗治疗5周左右出现红斑水疱,并逐渐加重,立即停用特瑞普利单抗,给予激素、人免疫球蛋白以及对症治疗后好转。结论特瑞普利单抗导致中毒性表皮坏死松解症后,应立即停药,并且立即启动激素治疗。
Objective To explore the strategy of toxic epidermal necrolysis caused by toripalimab in the treatment of patients with gastric adenocarcinoma.Methods The treatment process of 1 case of toripalimab-induced toxic epidermal necrolysis was analyzed.The pathogenesis,features and treatment of immune-related toxic epidermal necrolysis based on the literature review were explored.Results The patient developed erythematous blisters about 5 weeks after treatment with toripalimab,which gradually worsened.Toripalimab was withdrawn at once and the patient was given human immunoglobulin,hormone and symptomatic treatment.The skin symptoms were improved.Conclusion After toxic epidermal necrolysis caused by toripalimab develops,the drug should be discontinued immediately and hormone therapy should be initiated immediately.
作者
张丽
赵冰清
张艳华
ZHANG Li;ZHAO Bing-qing;ZHANG Yan-hua(Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Pharmacy,Peking University Cancer Hospital&Institute,Beijing 100142,China;Department of pharmacy,the Second Hospital of Anhui Medical University,Hefei 230601,China)
出处
《实用药物与临床》
CAS
2022年第7期643-645,共3页
Practical Pharmacy and Clinical Remedies
