摘要
肺癌是一种原发于支气管、气管和肺的恶性肿瘤,目前肺癌治疗虽已有较大改善,但由于化疗耐药、肿瘤异质性等问题,治疗效果仍不佳。自然杀伤(natural killer,NK)细胞是一种重要的免疫细胞,其数量减少、功能失调都可能使肿瘤细胞免疫逃逸而恶性发展。在肺癌发生发展中,NK细胞失衡介导了肺癌免疫逃逸,因而调控NK细胞活性治疗肺癌将是一种有效的策略。本文在综述NK细胞失衡介导肺癌免疫逃逸机理的基础上,重点总结了调控NK细胞免疫治疗肺癌的方法,如在细胞水平上的过继NK细胞疗法;在分子水平上调控NK细胞活性治疗肺癌的药物,如细胞因子诱导、免疫检查点抑制剂、ADCC效应的单抗、基于信号通路的靶向药物和从食药用菌/植物中提取的活性成分等。本综述阐述了NK细胞在肺癌免疫治疗中的潜力,旨在为肺癌治疗及药物研发提供参考。
Lung cancer is a malignant tumor that originating from the bronchus,trachea and lung.It has been greatly improved for the treatment of lung cancer,but the treatment effect is still poor due to chemotherapy resistance and tumor heterogeneity,etc.Natural killer(NK)cells are an important immune cell,whose decreased number and dysfunction will result in immune escape of tumor cells and further lead to malignant development of disease.In the occurrence and development of lung cancer,the imbalance of NK cells mediates the immune escape of tumor,so it is an effective therapeutic strategy to regulate the activity of NK cells for therapy lung cancer.This review summarized the mechanism of imbalanced NK cells mediated immune escape of lung cancer,focusing on the drugs that regulating the functions of NK cells for immunotherapy of lung cancer,such as adoptive NK cells therapy at the cellular level,and regulating the activity of NK cells at the molecular level,such as cytokines induction therapy,immune checkpoint inhibitors,ADCC-effected by monoclonal antibodies,targeted drugs based on signaling pathways,and active ingredients extracted from edible and medicinal fungi or plants,etc.This review clarifies the potential of NK cells for immunotherapy of lung cancer,aiming to provide reference for treatment of lung cancer and drug development.
作者
张月洋
王绮昀
何小花
金艳霞
ZHANG Yueyang;WANG Qiyun;HE Xiaohua;JIN Yanxia(College of Life Sciences,Hubei Key Laboratory of Edible Wild Plants Conservation and Utilization,Hubei Engineering Research Center of Special Wild Vegetables Breeding and Comprehensive Utilization Technology,National Demonstration Center for Experimental Biology Education,Hubei Normal University,Huangshi 435002,China)
出处
《生命的化学》
CAS
2022年第5期901-910,共10页
Chemistry of Life
基金
国家自然科学基金项目(32000908)
湖北省自然科学基金项目(2020CFB417)
湖北师范大学引进人才科研启动项目(HS2019RC008)。
关键词
肺癌
NK细胞
免疫
治疗
活性成分
lung cancer
NK cells
immune
therapy
active ingredients
