摘要
【目的】释放防御分泌物在生物的进化、天敌防御、信息传递及生长发育和繁殖过程中具有重要作用。本文旨在探究网络药理学方法用于生物防御分泌物研究的可行性。【方法】以九香虫Aspongopus chinensisDalls为例,在已知其防御分泌物成分的基础上,运用网络药理学和生物信息学方法分析生物分泌物的作用。【结果】九香虫防御分泌物成分复杂,且5/12的成分未在数据库中预测到靶点,相关研究缺乏;生物信息分析结果表明,防御分泌物的作用靶点分布广泛,在代谢、信息传递等生物进程及酶、受体功能活性等分子功能上扮演了重要角色,且可能与化学致癌、信息传递及生殖细胞成熟等多种通路密切相关。【结论】九香虫防御分泌物成分复杂,且具有信息传递和机体代谢等功能活性。
[Objectives]Defensive secretions play an important role in the evolution,growth and reproduction of organisms,and also in their defense against natural enemies and information transmission.This paper explores the application of network pharmacology in the study of defensive secretions,with the goal of providing some new ideas for the study of biological defense secretions.[Methods]We analyzed the possible effects of secretions of Aspongopus chinensis Dallas,based on the known components identified from network pharmacology and bioinformatics methods.[Results]The components of the defensive secretions of A.chinensis were complex,and the target of 5/12 components was not predicted by the database.Bioassay targets of secretions are widely distributed and play important roles in biological processes,such as metabolism and information transfer,as well as in molecular functions such as enzyme and receptor functional activities.They may also be closely related to chemical carcinogenesis,information transfer,germ cell maturation and other pathways.[Conclusion]The components of A.chinensis defense secretions are complex,and play functional roles in information transmission and metabolism.
作者
于姮梅
赵帅
郭建军
YU Heng-Mei;ZHAO Shuai;GUO Jian-Jun(Institute of Entomology,Guizhou University/Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region/cientific Observing and Experimental Station of Crop Pest in Guiyang,Ministry of Agriculture and Rural Affairs of the P.R.China,Guiyang 550025,China)
出处
《应用昆虫学报》
CAS
CSCD
北大核心
2022年第3期662-670,共9页
Chinese Journal of Applied Entomology
基金
澜沧江-湄公河地区食用昆虫资源评价及合作开发(教外司亚【2020】619号)。
关键词
生物防御分泌物
九香虫
网络药理学
生物信息学
化学致癌作用
biological defense secretions
Aspongopus chinensis
network pharmacology
bioinformatics
chemical carcinogenesis
